Phenotypes associated with this allele

• Allele Symbol: Ttc4^em1(IMPC)Bay
• Allele Name: endonuclease-mediated mutation 1, Baylor College of Medicine
• Allele ID: MGI:7426060
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ttc4^em1(IMPC)Bay/Ttc4^em1(IMPC)Bay	C57BL/6NJ-Ttc4^em1(IMPC)Bay/Mmnc	MGI:7720022
hm2	Ttc4^em1(IMPC)Bay/Ttc4^em1(IMPC)Bay	C57BL/6N-Ttc4^em1(IMPC)Bay/BayMmucd	MGI:7551253
ht3	Ttc4^em1(IMPC)Bay/Ttc4^+	C57BL/6N-Ttc4^em1(IMPC)Bay/BayMmucd	MGI:7472305

Genotype
MGI:7720022

hm1

• Allelic Composition: Ttc4^em1(IMPC)Bay/Ttc4^em1(IMPC)Bay
• Genetic Background: C57BL/6NJ-Ttc4^em1(IMPC)Bay/Mmnc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ttc4^em1(IMPC)Bay/Ttc4^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as dying morulae but not at E7.5. Embryos show no further development after 3 days in culture.

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:279207 )

• homozygous embryos are present in nearly normal Mendelian ratios at E3.5 and appear as dying morulae; no homozygous embryos are recovered at E7.5

embryo

embryonic growth arrest ( J:279207 )

• in vitro, embryos show no further development after 3 days in culture

abnormal morula morphology ( J:279207 )

• embryos recovered at E3.5 appear as dying morulae

reproductive system

failure of embryo implantation ( J:279207 )

• in vitro, embryos never form outgrowths after 3 days in culture

Genotype
MGI:7551253

hm2

• Allelic Composition: Ttc4^em1(IMPC)Bay/Ttc4^em1(IMPC)Bay
• Genetic Background: C57BL/6N-Ttc4^em1(IMPC)Bay/BayMmucd

Data Sources

IMPC Data for Ttc4

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM

Genotype
MGI:7472305

ht3

• Allelic Composition: Ttc4^em1(IMPC)Bay/Ttc4⁺
• Genetic Background: C57BL/6N-Ttc4^em1(IMPC)Bay/BayMmucd

Data Sources

IMPC Data for Ttc4

behavior/neurological

limb grasping ( J:211773 )

IMPC - BCM