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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gakem1(IMPC)Ccpcz
endonuclease-mediated mutation 1, Institute of Molecular Genetics
MGI:7425701
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gakem1(IMPC)Ccpcz/Gakem1(IMPC)Ccpcz C57BL/6NCrl-Gakem1(IMPC)Ccpcz/Ccpcz MGI:7768340
ht2
 		Gakem1(IMPC)Ccpcz/Gak+ C57BL/6NCrl-Gakem1(IMPC)Ccpcz/Ccpcz MGI:7629003


Genotype
MGI:7768340
hm1
Allelic
Composition		 Gakem1(IMPC)Ccpcz/Gakem1(IMPC)Ccpcz
Genetic
Background		 C57BL/6NCrl-Gakem1(IMPC)Ccpcz/Ccpcz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gakem1(IMPC)Ccpcz mutation (1 available); any Gak mutation (60 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

cardiovascular system

mortality/aging




Genotype
MGI:7629003
ht2
Allelic
Composition		 Gakem1(IMPC)Ccpcz/Gak+
Genetic
Background		 C57BL/6NCrl-Gakem1(IMPC)Ccpcz/Ccpcz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gakem1(IMPC)Ccpcz mutation (1 available); any Gak mutation (60 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
enlarged heart ( J:211773 )
IMPC - CCP-IMG

endocrine/exocrine glands
enlarged thymus ( J:211773 )
IMPC - CCP-IMG

growth/size/body
enlarged heart ( J:211773 )
IMPC - CCP-IMG
enlarged kidney ( J:211773 )
IMPC - CCP-IMG
increased kidney weight ( J:211773 )
IMPC - CCP-IMG
enlarged spleen ( J:211773 )
IMPC - CCP-IMG

hematopoietic system
enlarged thymus ( J:211773 )
IMPC - CCP-IMG
enlarged spleen ( J:211773 )
IMPC - CCP-IMG

immune system
enlarged thymus ( J:211773 )
IMPC - CCP-IMG
enlarged spleen ( J:211773 )
IMPC - CCP-IMG

integument

renal/urinary system
enlarged kidney ( J:211773 )
IMPC - CCP-IMG




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory