Phenotypes associated with this allele

• Allele Symbol: Dbi^tm1.1Krog
• Allele Name: targeted mutation 1.1, Guido Kroemer
• Allele ID: MGI:7414380
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dbi^tm1.1Krog/Dbi^tm1.1Krog Ndor1^Tg(UBC-cre/ERT2)1Ejb/Ndor1^+	involves: 129 * C57BL/6 * C57BL/6J	MGI:8433214
cn2	Dbi^tm1.1Krog/Dbi^tm1.1Krog Tg(Ttr-cre/Esr1*)1Vco/0	involves: C57BL/6 * C57BL/6J * DBA/2	MGI:8433215

Genotype
MGI:8433214

cn1

• Allelic Composition: Dbi^tm1.1Krog/Dbi^tm1.1Krog; Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/Ndor1⁺
• Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:376151 )

• tamoxifen-treated mice administered high-dose corticosterone (CORT) for 5 weeks to induce Cushings syndrome show reduced CORT-induced appetite and weight gain, and attenuated CORT-induced hepatomegaly, expansion of adipose tissues, atrophy of skeletal muscle, dyslipidemia, insulin resistance, fasting plasma glucose, HOMA-IR values and alternations in glucose tolerate test and insulin tolerance test indicating the prevention of the metabolic consequences of chronic glucocorticoid administration

Genotype
MGI:8433215

cn2

• Allelic Composition: Dbi^tm1.1Krog/Dbi^tm1.1Krog; Tg(Ttr-cre/Esr1*)1Vco/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

homeostasis/metabolism

abnormal response/metabolism to endogenous compounds ( J:376151 )

• tamoxifen-treated mice administered high-dose corticosterone (CORT) for 5 weeks to induce Cushings syndrome show reduced CORT-induced food intake and weight gain and attenuated CORT-induced hepatomegaly, dyslipidemia, insulin resistance, fasting plasma glucose, and HOMA-IR values, indicating the prevention of the metabolic consequences of chronic glucocorticoid administration