Phenotypes associated with this allele

• Allele Symbol: Grpel1^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:7410924
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Grpel1^tm1c(EUCOMM)Wtsi/Grpel1^tm1c(EUCOMM)Wtsi Tg(ACTA1-cre/ERT2)97.16Mtz/0	involves: C57BL/6N	MGI:7411110

Genotype
MGI:7411110

cn1

• Allelic Composition: Grpel1^{tm1c(EUCOMM)Wtsi}/Grpel1^{tm1c(EUCOMM)Wtsi}; Tg(ACTA1-cre/ERT2)97.16Mtz/0
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal skeletal muscle morphology ( J:330869 )

• disorganized in tamoxifen-treated mice

decreased skeletal muscle fiber diameter ( J:330869 )

• in tamoxifen-treated mice

skeletal muscle atrophy ( J:330869 )

• in tamoxifen-treated mice

skeletal muscle fibrosis ( J:330869 )

• in tamoxifen-treated mice

abnormal muscle physiology ( J:330869 )

• systemic metabolic alterations with decreased glycolysis and increased fatty acids in muscles of tamoxifen-treated mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:330869 )

N • tamoxifen-treated mice exhibit normal oxygen consumption, respiratory exchange ratio, heat production, glucose tolerance, and insulin sensitivity

decreased circulating glucose level ( J:330869 )

• in tamoxifen-treated mice at end point

growth/size/body

weight loss ( J:330869 )

• in tamoxifen-treated mice without a change in movement, oxygen consumption, respiratory exchange ratio, or heat production

behavior/neurological

decreased grip strength ( J:330869 )

• in tamoxifen-treated mice