Phenotypes associated with this allele

• Allele Symbol: Hpcal1^em1Ylzg
• Allele Name: endonuclease-mediated mutation 1, Yonglong Zhang
• Allele ID: MGI:7407147
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hpcal1^em1Ylzg/Hpcal1^em1Ylzg	C57BL/6J-Hpcal1^em1Ylzg	MGI:7407158

Genotype
MGI:7407158

hm1

• Allelic Composition: Hpcal1^em1Ylzg/Hpcal1^em1Ylzg
• Genetic Background: C57BL/6J-Hpcal1^em1Ylzg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:331711 )

• in mice treated with diethylnitrosamine/CCl4

neoplasm

increased incidence of tumors by chemical induction ( J:331711 )

• increased tumor burden and shortened survival in mice treated with diethylnitrosamine/CCl4

abnormal tumor morphology ( J:331711 )

• increased triglycerides and cholesterol in the tumors of mice treated with diethylnitrosamine/CCl4 with bigger and greater lipid droplets

liver/biliary system

increased liver weight ( J:331711 )

• in mice treated with diethylnitrosamine/CCl4

homeostasis/metabolism

increased circulating alanine level ( J:331711 )

increased circulating aspartate transaminase level ( J:331711 )

increased susceptibility to xenobiotic induced morbidity/mortality ( J:331711 )

• in mice treated with diethylnitrosamine/CCl4

increased incidence of tumors by chemical induction ( J:331711 )

• increased tumor burden and shortened survival in mice treated with diethylnitrosamine/CCl4

growth/size/body

increased liver weight ( J:331711 )

• in mice treated with diethylnitrosamine/CCl4