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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sp140em1Vnce
endonuclease-mediated mutation 1, Russell E Vance
MGI:7386886
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sp140em1Vnce/Sp140em1Vnce C57BL/6J-Sp140em1Vnce MGI:7386891
cx2
 		Ifnar1tm1Agt/Ifnar1tm1Agt
Sp140em1Vnce/Sp140em1Vnce 		B6.Cg-Sp140em1Vnce Ifnar1tm1Agt MGI:7386893


Genotype
MGI:7386891
hm1
Allelic
Composition		 Sp140em1Vnce/Sp140em1Vnce
Genetic
Background		 C57BL/6J-Sp140em1Vnce
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp140em1Vnce mutation (0 available); any Sp140 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
increased susceptibility to bacterial infection ( J:313901 )
• mice exhibit increased susceptibility to M. tuberculosis infection compared with wild-type mice




Genotype
MGI:7386893
cx2
Allelic
Composition		 Ifnar1tm1Agt/Ifnar1tm1Agt
Sp140em1Vnce/Sp140em1Vnce
Genetic
Background		 B6.Cg-Sp140em1Vnce Ifnar1tm1Agt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnar1tm1Agt mutation (13 available); any Ifnar1 mutation (62 available)
Sp140em1Vnce mutation (0 available); any Sp140 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:313901 )
N
• mice exhibit normal susceptibility to M. tuberculosis infection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory