All Phenotypes Sp140<em1Vnce> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Sp140^em1Vnce
endonuclease-mediated mutation 1, Russell Vance
MGI:7386886

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sp140^em1Vnce/Sp140^em1Vnce	C57BL/6J-Sp140^em1Vnce	MGI:7386891
cx2	Ifnar1^tm1Agt/Ifnar1^tm1Agt Sp140^em1Vnce/Sp140^em1Vnce	B6.Cg-Sp140^em1Vnce Ifnar1^tm1Agt	MGI:7386893

Allelic Composition	Sp140^em1Vnce/Sp140^em1Vnce
Genetic Background	C57BL/6J-Sp140^em1Vnce

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp140^em1Vnce mutation (0 available); any Sp140 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:313901 )

• in mice infected with M. tuberculosis

immune system

increased susceptibility to bacterial infection ( J:313901 )

• mice exhibit increased susceptibility to M. tuberculosis infection compared with wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:313901 )

• in mice infected with M. tuberculosis

Allelic Composition	Ifnar1^tm1Agt/Ifnar1^tm1Agt Sp140^em1Vnce/Sp140^em1Vnce
Genetic Background	B6.Cg-Sp140^em1Vnce Ifnar1^tm1Agt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnar1^tm1Agt mutation (11 available); any Ifnar1 mutation (59 available)
Sp140^em1Vnce mutation (0 available); any Sp140 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:313901 )

N	• mice exhibit normal susceptibility to M. tuberculosis infection

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