Phenotypes associated with this allele

• Allele Symbol: Lrtm2^tm1.1Jaru
• Allele Name: targeted mutation 1.1, Jun Aruga
• Allele ID: MGI:7378323
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lrtm2^tm1.1Jaru/Lrtm2^tm1.1Jaru	B6.129P2-Lrtm2^tm1.1Jaru	MGI:7378326

Genotype
MGI:7378326

hm1

• Allelic Composition: Lrtm2^tm1.1Jaru/Lrtm2^tm1.1Jaru
• Genetic Background: B6.129P2-Lrtm2^tm1.1Jaru

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:325069 )

N • mice exhibit normal performance in elevated plus maze, light- dark box test, elevated plus maze test, fear conditioning test, forced swimming test, hot plate test, tail-flick test, acoustic startle response test, marble burying test, and social interaction tests

increased coping response ( J:325069 )

• reduced immobility in a tail suspension test

abnormal response to novelty ( J:325069 )

• in a hole board test, mice take longer to investigate holes and spend shorter time investigating compared with wild-type mice

abnormal response to novel object ( J:325069 )

• mice take longer to approach an inanimate novel object compared with wild-type mice

enhanced coordination ( J:325069 )

• at 15 months, mice remain longer on a rotating rod compared with wild-type mice

decreased social investigation ( J:325069 )

• in a social discrimination test, mice spent shorter time near the cylinder cage with a mouse compared with wild-type mice

homeostasis/metabolism

decreased nervous system dopamine level ( J:325069 )

• reduced DOPAC in the dorsal striatum and hypothalamus

increased noradrenaline level ( J:325069 )

• slightly in young mice

decreased serotonin level ( J:325069 )

• reduced 5HIAA in the hypothalamus and increased 5-HT turnover in the amygdala and dorsal striatum

growth/size/body

decreased body weight ( J:325069 )

• slightly