Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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embryo
N |
• born at expected Mendelian ratios
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growth/size/body
mortality/aging
nervous system
N |
• normal neuro- and adenohypophysis development
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reproductive system
Allelic Composition |
Rr115em1Bobh/Rr115+ Shhtm1Chg/Shh+
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr115em1Bobh mutation
(0 available);
any
Rr115 mutation
(0 available)
Shhtm1Chg mutation
(1 available);
any
Shh mutation
(45 available)
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craniofacial
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• reduced in size or absent in E17.5 embryos
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• excessively fused or absent in E17.5 embryos
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• reduced length in E17.5 embryos
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endocrine/exocrine glands
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• absent oxytocin and vasopressin expressing cells in paraventricular nucleus (PVN) in E15.5 embryos
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• absent oxytocin, tyrosine hydroxylase (TH1) and vasopressin expressing cells in paraventricular nucleus (PVN) in E15.5 embryos
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• mislocated in E17.5 embryos, intercepting the basisphenoid bone
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• shifted ventrally in E11.5 embryos
• severely malformed in E13.5 embryos
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• less separation of infundibulum from neuroectodermal tissue in E13.5 embryos
• undergoing apoptosis in E17.5 embryos
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• infundibulum shifted ventrally in E11.5 embryos, remaining ectopic in E15.5 embryos
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growth/size/body
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• reduced length in E17.5 embryos
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mortality/aging
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• expected Mendelian ratios at stage E17.5
• premature death by age P4
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nervous system
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• mislocated in E17.5 embryos, intercepting the basisphenoid bone
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• shifted ventrally in E11.5 embryos
• severely malformed in E13.5 embryos
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• less separation of infundibulum from neuroectodermal tissue in E13.5 embryos
• undergoing apoptosis in E17.5 embryos
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• infundibulum shifted ventrally in E11.5 embryos, remaining ectopic in E15.5 embryos
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• midline hypothalamic brain tissue absent in E17.5 embryos
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• absent oxytocin and vasopressin expressing cells in paraventricular nucleus (PVN) in E15.5 embryos
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• absent oxytocin, tyrosine hydroxylase (TH1) and vasopressin expressing cells in paraventricular nucleus (PVN) in E15.5 embryos
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respiratory system
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• reduced length in E17.5 embryos
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skeleton
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• reduced in size or absent in E17.5 embryos
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• excessively fused or absent in E17.5 embryos
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