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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sepsecstm1.1Usch
targeted mutation 1.1, Ulrich Schweizer
MGI:7367126
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sepsecstm1.1Usch/Sepsecstm1.1Usch 129.Cg-Sepsecstm1.1Usch MGI:7367144
hm2
Sepsecstm1.1Usch/Sepsecstm1.1Usch B6.Cg-Sepsecstm1.1Usch MGI:7367146
cx3
Gpx4tm5Marc/Gpx4+
Sepsecstm1.1Usch/Sepsecstm1.1Usch
involves: 129S6/SvEvTac * C57BL/6J MGI:7367143


Genotype
MGI:7367144
hm1
Allelic
Composition
Sepsecstm1.1Usch/Sepsecstm1.1Usch
Genetic
Background
129.Cg-Sepsecstm1.1Usch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sepsecstm1.1Usch mutation (0 available); any Sepsecs mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• authors state that mice exhibit the same phenotype as mice on a congenic C57BL/6 background

respiratory system
• authors state that mice exhibit the same phenotype as mice on a congenic C57BL/6 background




Genotype
MGI:7367146
hm2
Allelic
Composition
Sepsecstm1.1Usch/Sepsecstm1.1Usch
Genetic
Background
B6.Cg-Sepsecstm1.1Usch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sepsecstm1.1Usch mutation (0 available); any Sepsecs mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all mice die within the first day after birth

respiratory system
• shallow and irregular breathing develops after birth
• however, mice are born with normal breathing frequency

homeostasis/metabolism
• at P0

growth/size/body
• in some mice

behavior/neurological




Genotype
MGI:7367143
cx3
Allelic
Composition
Gpx4tm5Marc/Gpx4+
Sepsecstm1.1Usch/Sepsecstm1.1Usch
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx4tm5Marc mutation (0 available); any Gpx4 mutation (80 available)
Sepsecstm1.1Usch mutation (0 available); any Sepsecs mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mice exhibit normal survival

cardiovascular system
• slightly decreased

respiratory system
N
• mice exhibit normal breathing frequency





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory