Phenotypes associated with this allele

• Allele Symbol: Rr291^tm1.1Mekk
• Allele Name: targeted mutation 1.1, Marc Ekker
• Allele ID: MGI:7356587
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr291^tm1.1Mekk/Rr291^tm1.1Mekk	involves: 129S/SvEv * C57BL/6N	MGI:7356615
cx2	Rr291^tm1.1Mekk/Rr291^tm1.1Mekk Rr293^tm1.1Mekk/Rr293^tm1.1Mekk	involves: 129S/SvEv * C57BL/6N	MGI:7356618

Genotype
MGI:7356615

hm1

• Allelic Composition: Rr291^tm1.1Mekk/Rr291^tm1.1Mekk
• Genetic Background: involves: 129S/SvEv * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:312374 )

N • normal behavior in beam brake, elevated plus maze and open field tests

impaired cued conditioning behavior ( J:312374 )

nervous system

abnormal GABAergic neuron morphology ( J:312374 )

• reduced number in the lateral ganglionic eminence (LGE) in E13.5 embryos

• normal number in somatosensory cortex at age P35

mortality/aging

mortality/aging ( J:312374 )

N • viable

embryo

embryo phenotype ( J:312374 )

N • no obvious developmental phenotype

reproductive system

reproductive system phenotype ( J:312374 )

N • fertile

Genotype
MGI:7356618

cx2

• Allelic Composition: Rr291^tm1.1Mekk/Rr291^tm1.1Mekk; Rr293^tm1.1Mekk/Rr293^tm1.1Mekk
• Genetic Background: involves: 129S/SvEv * C57BL/6N

behavior/neurological

behavior/neurological phenotype ( J:312374 )

N • normal behavior in beam brake, elevated plus maze and open field tests

impaired cued conditioning behavior ( J:312374 )

increased social investigation ( J:312374 )

• increased interaction with juvenile