Phenotypes associated with this allele

• Allele Symbol: Rr268^em1Hino
• Allele Name: endonuclease-mediated mutation 1, Hirofumi Noguchi
• Allele ID: MGI:7338993
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr268^em1Hino/Rr268^em1Hino	C57BL/6J-Rr268^em1Hino	MGI:7339117
cx2	Rr266^em1Hino/Rr266^em1Hino Rr268^em1Hino/Rr268^em1Hino	C57BL/6J-Rr266^em1Hino Rr268^em1Hino	MGI:7339120

Genotype
MGI:7339117

hm1

• Allelic Composition: Rr268^em1Hino/Rr268^em1Hino
• Genetic Background: C57BL/6J-Rr268^em1Hino

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:312429 )

• no diabetes or hyperglycemia; normal glucose tolerance and insulin levels

Genotype
MGI:7339120

cx2

• Allelic Composition: Rr266^em1Hino/Rr266^em1Hino; Rr268^em1Hino/Rr268^em1Hino
• Genetic Background: C57BL/6J-Rr266^em1Hino Rr268^em1Hino

endocrine/exocrine glands

decreased insulin secretion ( J:312429 )

growth/size/body

decreased body weight ( J:312429 )

• at ages 6 and 12 weeks

homeostasis/metabolism

decreased insulin secretion ( J:312429 )

hyperglycemia ( J:312429 )

• increased blood glucose levels after feeding and after fasting at ages 6 and 12 weeks

impaired glucose tolerance ( J:312429 )

• increased blood glucose levels after glucose administration

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
diabetes mellitus		DOID:9351		J:312429