Phenotypes associated with this allele

• Allele Symbol: Phf21b^em1Mlwg
• Allele Name: endonuclease-mediated mutation 1, Ma-Li Wong
• Allele ID: MGI:7335174
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Phf21b^em1Mlwg/Phf21b^em1Mlwg	C57BL/6J-Phf21b^em1Mlwg	MGI:7336224

Genotype
MGI:7336224

hm1

• Allelic Composition: Phf21b^em1Mlwg/Phf21b^em1Mlwg
• Genetic Background: C57BL/6J-Phf21b^em1Mlwg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

thin cerebral cortex ( J:328040 )

• with reduced number of immature neurons

decreased astrocyte number ( J:328040 )

• without an increase in apoptosis

abnormal neurite morphology ( J:328040 )

• reduced total neurite length

• however, the total number of branches is normal

abnormal dendritic thin spine morphology ( J:328040 )

• larger proportion of thin spines compared with wild-type neurons

decreased neuron number ( J:328040 )

• reduced number of immature neurons

reduced long-term potentiation ( J:328040 )

behavior/neurological

behavior/neurological phenotype ( J:328040 )

N • mice exhibit no anxiety-like behaviors in an open field or elevated plus-maze, no behavioral despair, and normal learning and long-term spatial reference memory

impaired social recognition ( J:328040 )

• deficit in social memory indicated by a failure to recognize a familiar stranger they have habituated with

• however, novel stranger recognition is normal