Phenotypes associated with this allele

• Allele Symbol: Tubb4b^em1Golab
• Allele Name: endonuclease-mediated mutation 1, Genetic in Ophtalmology Laboratory
• Allele ID: MGI:7334857
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tubb4b^em1Golab/Tubb4b^+	C57BL/6J-Tubb4b^em1Golab	MGI:8328256

Genotype
MGI:8328256

ht1

• Allelic Composition: Tubb4b^em1Golab/Tubb4b⁺
• Genetic Background: C57BL/6J-Tubb4b^em1Golab

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal spermatogenesis ( J:360308 )

♂

male infertility ( J:360308 )

♂

respiratory system

abnormal respiratory motile cilium morphology ( J:360308 )

• 20% reduction in airway cilia length

cellular

abnormal respiratory motile cilium morphology ( J:360308 )

• 20% reduction in airway cilia length

vision/eye

vision/eye phenotype ( J:360308 )

N • mice do not develop retinal degeneration, even when aged

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Leber congenital amaurosis with early-onset deafness	DOID:0112240	OMIM:617879	J:360308