Phenotypes associated with this allele

• Allele Symbol: Clk4^em1Yihc
• Allele Name: endonuclease-mediated mutation 1, Yi-Han Chen
• Allele ID: MGI:7333070
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+ Clk4^em1Yihc/Clk4^em1Yihc	B6(FVB)-Clk4^em1Yihc A1cf^Tg(Myh6-cre/Esr1*)1Jmk	MGI:7333095

Genotype
MGI:7333095

cn1

• Allelic Composition: A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺; Clk4^em1Yihc/Clk4^em1Yihc
• Genetic Background: B6(FVB)-Clk4^em1Yihc A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:327369 )

• increased cross-sectional area without change in length in tamoxifen-treated mice

myocardium hypertrophy ( J:327369 )

• in tamoxifen-treated mice

• however, overexpression of a phosphorylation-mimic mutant of NEXN (S437E) rescues cardiac hypertrophy

increased heart weight ( J:327369 )

• in tamoxifen-treated mice

increased heart left ventricle size ( J:327369 )

• in tamoxifen-treated mice

cardiac interstitial fibrosis ( J:327369 )

• in tamoxifen-treated mice

• however, overexpression of a phosphorylation-mimic mutant of NEXN (S437E) rescues fibrosis

decreased ventricle muscle contractility ( J:327369 )

congestive heart failure ( J:327369 )

• rapid onset in tamoxifen-treated mice with decreased left ventricular internal diameter, diastole, and a significant decrease in the left ventricular ejection fraction

growth/size/body

myocardium hypertrophy ( J:327369 )

• in tamoxifen-treated mice

• however, overexpression of a phosphorylation-mimic mutant of NEXN (S437E) rescues cardiac hypertrophy

increased heart weight ( J:327369 )

• in tamoxifen-treated mice

increased lung weight ( J:327369 )

• in tamoxifen-treated mice

muscle

increased myocardial fiber size ( J:327369 )

• increased cross-sectional area without change in length in tamoxifen-treated mice

myocardium hypertrophy ( J:327369 )

• in tamoxifen-treated mice

• however, overexpression of a phosphorylation-mimic mutant of NEXN (S437E) rescues cardiac hypertrophy

decreased ventricle muscle contractility ( J:327369 )

abnormal sarcomere morphology ( J:327369 )

• disrupted integrity ruptured myofilaments, blurred Z-disk, and mitochondrial abnormalities in cardiomyocytes of tamoxifen-treated mice

diffuse Z line ( J:327369 )

• in cardiomyocytes of tamoxifen-treated mice

respiratory system

increased lung weight ( J:327369 )

• in tamoxifen-treated mice

cellular

cardiac interstitial fibrosis ( J:327369 )

• in tamoxifen-treated mice

• however, overexpression of a phosphorylation-mimic mutant of NEXN (S437E) rescues fibrosis