Analysis Tools
nervous system
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• adults show pathological appearing axons in optic nerves (axonopathy) 4 months after tamoxifen injection
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Allele Symbol Allele Name Allele ID |
Cmtm5tm1c(KOMP)Wtsi targeted mutation 1c, Wellcome Trust Sanger Institute MGI:7330365 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• adults show pathological appearing axons in optic nerves (axonopathy) 4 months after tamoxifen injection
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• concentration of myo-inositol is increased in the corpus callosi at 8 months of age, indicating gliosis
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• late-onset astrogliosis
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• mice show early-onset progressive axonopathy, with optic nerves showing pathological axonal profiles already at P30 and their number progressively increasing
• mice show a trend toward reduced axon density is seen at P30 and P75 which reaches significance at 12 months of age and leads to axonal loss
• dorsal white matter in spinal cords shows axonopathy in 12-month-old mice
• however, mice show normal axonal diameters in the optic nerves
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• number of myelin whorls (multilamellar structures that display the periodicity of CNS myelin devoid of a discernible axon; i.e. remnants of degenerating myelinated fibers with relative sparing of myelin membranes) is increased in optic nerves of 12-month-old mice, indicating axonal degeneration but not myelin pathology
• however, mice show normal myelin biogenesis and composition and numbers of myelin outfoldings, normal myelin sheath thickness, unchanged inner-tongue inclusions and axoplasmic inclusions, and normal mature oligodendrocytes
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• visually evoked potential amplitudes are reduced indicating that transmission of signals via the optic nerves to the visual cortex is impaired
• however, mice show sizeable visually evoked potentials with normal thresholds and latency, indicating normal speed of action potential propagation
• electroretinography shows normal ERG waveforms, thresholds, and amplitudes of a- and b-waves at 8.5 months of age indicating normal retinal function
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• concentration of myo-inositol is increased in the corpus callosi at 8 months of age, indicating gliosis
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• concentration of myo-inositol is increased in the corpus callosi at 8 months of age, indicating gliosis
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| N |
• mice show no obvious behavioral phenotype
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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