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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trgv7em1Dmuc
endonuclease-mediated mutation 1, Daniel Mucida
MGI:7328936
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Trgv7em1Dmuc/Trgv7em1Dmuc C57BL/6-Trgv7em1Dmuc MGI:8449414
ht2
 		Trgv7em1Dmuc/Trgv7+ C57BL/6-Trgv7em1Dmuc MGI:8459983


Genotype
MGI:8449414
hm1
Allelic
Composition		 Trgv7em1Dmuc/Trgv7em1Dmuc
Genetic
Background		 C57BL/6-Trgv7em1Dmuc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trgv7em1Dmuc mutation (1 available); any Trgv7 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased gamma-delta intraepithelial T cell number ( J:327132 )
• intestine shows an overall reduction of intestinal intraepithelial gamma-delta T cells
• mice subjected to azoxymethane-dextran sodium sulfate (AOM-DSS) show a reduction in TCRgamma-delta cells in nontumor areas but the frequencies of IFN-gamma, PD-1, and IL-17 expression by gamma-delta T cells is similar to controls
abnormal CD8-positive, alpha-beta intraepithelial T cell morphology ( J:327132 )
• mice show an increase in the frequency of TCRalpha-beta+CD8alpha-alpha+ natural intestinal intraepithelial lymphocytes
• however, tumor-infiltrating TCRalpha-beta+CD4+ and TCRalpha-beta+CDl8alpha+ cells do not show differences in cytokine production

immune system
decreased gamma-delta intraepithelial T cell number ( J:327132 )
• intestine shows an overall reduction of intestinal intraepithelial gamma-delta T cells
• mice subjected to azoxymethane-dextran sodium sulfate (AOM-DSS) show a reduction in TCRgamma-delta cells in nontumor areas but the frequencies of IFN-gamma, PD-1, and IL-17 expression by gamma-delta T cells is similar to controls
abnormal CD8-positive, alpha-beta intraepithelial T cell morphology ( J:327132 )
• mice show an increase in the frequency of TCRalpha-beta+CD8alpha-alpha+ natural intestinal intraepithelial lymphocytes
• however, tumor-infiltrating TCRalpha-beta+CD4+ and TCRalpha-beta+CDl8alpha+ cells do not show differences in cytokine production

neoplasm
neoplasm ( J:327132 )
N
• mice subjected to AOM-DSS do not show differences in colorectal tumor number, size, or burden from controls




Genotype
MGI:8459983
ht2
Allelic
Composition		 Trgv7em1Dmuc/Trgv7+
Genetic
Background		 C57BL/6-Trgv7em1Dmuc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trgv7em1Dmuc mutation (1 available); any Trgv7 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased gamma-delta intraepithelial T cell number ( J:327132 )
• intestine shows a reduction, albeit to a lesser degree than in homozygotes, of intestinal intraepithelial gamma-delta T cells

immune system
decreased gamma-delta intraepithelial T cell number ( J:327132 )
• intestine shows a reduction, albeit to a lesser degree than in homozygotes, of intestinal intraepithelial gamma-delta T cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory