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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem95em1Nino
endonuclease-mediated mutation 1, Naokazu Inoue
MGI:7327523
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmem95em1Nino/Tmem95em1Nino involves: C57BL/6 * DBA/2J MGI:7327527


Genotype
MGI:7327527
hm1
Allelic
Composition		 Tmem95em1Nino/Tmem95em1Nino
Genetic
Background		 involves: C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem95em1Nino mutation (1 available); any Tmem95 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reduced male fertility ( J:324885 )
• male mice produce half the expected litter size as wild-type mice
failure of sperm-egg fusion ( J:324885 )
• almost all spermatozoa fail to fuse with oocytes and longer exposure does not improve fertilization rates
• however, sperm motility is normal
decreased fertilization frequency ( J:324885 )
• almost all spermatozoa fail to fuse with oocytes and longer exposure does not improve fertilization rates




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory