Phenotypes associated with this allele

• Allele Symbol: Akip1^em1Cya
• Allele Name: endonuclease-mediated mutation 1, Cyagen Biosciences
• Allele ID: MGI:7327293
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akip1^em1Cya/Akip1^em1Cya	C57BL/6N-Akip1^em1Cya	MGI:7327415

Genotype
MGI:7327415

hm1

• Allelic Composition: Akip1^em1Cya/Akip1^em1Cya
• Genetic Background: C57BL/6N-Akip1^em1Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to endotoxin shock ( J:326919 )

• mice infected with an adenovirus expressing Ebola virus VP35 exhibit lower mortality rates than wild-type mice when challenged with LPS

decreased susceptibility to viral infection ( J:326919 )

• mice infected with an adenovirus expressing Ebola virus virion protein 35 (VP35) do not show an increase in thrombomodulin levels, prolonged prothrombin time, reduced fibrinogen level or prolonged tail bleeding time as seen in wild-type mice

homeostasis/metabolism

decreased bleeding time ( J:326919 )

• mice infected with an adenovirus expressing Ebola virus VP35 do not show prolonged tail bleeding time as in wild-type mice

decreased prothrombin time ( J:326919 )

• mice infected with an adenovirus expressing Ebola virus VP35 do not show prolonged prothrombin time as seen in infected wild-type mice