About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcfl5tm1Frem
targeted mutation 1, Manuel Fresno
MGI:7316451
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Tcfl5tm1Frem/Tcfl5tm1Frem
Tg(CAG-cre/Esr1*)5Amc/0 		involves: C57BL/6 * CBA MGI:7316744


Genotype
MGI:7316744
cn1
Allelic
Composition		 Tcfl5tm1Frem/Tcfl5tm1Frem
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcfl5tm1Frem mutation (0 available); any Tcfl5 mutation (10 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
azoospermia ( J:326601 )
• adult tamoxifen-treated males lack spermatozoa in the seminiferous tubule lumen
abnormal spermatid morphology ( J:326601 )
• adult tamoxifen-treated males show alterations in spermatid elongation resulting in aberrant spermatid morphology
multinucleated giant male germ cells ( J:326601 )
• adult tamoxifen-treated males exhibit multinucleated round giant cells containing primary spermatocytes in most seminiferous tubules
abnormal seminiferous tubule morphology ( J:326601 )
• adult tamoxifen-treated males show abnormal tubule morphology features, including multinucleated rounded giant cells containing primary spermatocytes, a decreased number of elongated spermatids, and no spermatozoa in the lumen
small testis ( J:326601 )
• adult tamoxifen-treated males exhibit a significantly smaller testis size than control males
decreased testis weight ( J:326601 )
• adult tamoxifen-treated males exhibit a significantly lower testis weight than control males
abnormal spermiogenesis ( J:326601 )
• adult tamoxifen-treated males show a 4.5-fold increase in the % of elongated spermatids with aberrant morphology relative to non-treated control males

cellular
azoospermia ( J:326601 )
• adult tamoxifen-treated males lack spermatozoa in the seminiferous tubule lumen
abnormal spermatid morphology ( J:326601 )
• adult tamoxifen-treated males show alterations in spermatid elongation resulting in aberrant spermatid morphology
multinucleated giant male germ cells ( J:326601 )
• adult tamoxifen-treated males exhibit multinucleated round giant cells containing primary spermatocytes in most seminiferous tubules

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:326601 )
• adult tamoxifen-treated males show abnormal tubule morphology features, including multinucleated rounded giant cells containing primary spermatocytes, a decreased number of elongated spermatids, and no spermatozoa in the lumen
small testis ( J:326601 )
• adult tamoxifen-treated males exhibit a significantly smaller testis size than control males
decreased testis weight ( J:326601 )
• adult tamoxifen-treated males exhibit a significantly lower testis weight than control males




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory