Phenotypes associated with this allele

• Allele Symbol: Igs2^{tm1(CAG-Ptgs2os)Scrp}
• Allele Name: targeted mutation 1, Susan Carpenter
• Allele ID: MGI:7314909
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igs2^tm1(CAG-Ptgs2os)Scrp/Igs2^tm1(CAG-Ptgs2os)Scrp	involves: C57BL/6	MGI:7314911
cx2	Igs2^tm1(CAG-Ptgs2os)Scrp/Igs2^tm1(CAG-Ptgs2os)Scrp Ptgs2os^em1Scrp/Ptgs2os^em1Scrp	involves: C57BL/6	MGI:7314912

Genotype
MGI:7314911

hm1

• Allelic Composition: Igs2^{tm1(CAG-Ptgs2os)Scrp}/Igs2^{tm1(CAG-Ptgs2os)Scrp}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating cytokine level ( J:325487 )

• LPS-treated mice exhibit increased serum levels of Csf1 and IL10 compared with wild-type mice

increased circulating interleukin-10 level ( J:325487 )

• in LPS-treated mice

immune system

abnormal circulating cytokine level ( J:325487 )

• LPS-treated mice exhibit increased serum levels of Csf1 and IL10 compared with wild-type mice

increased circulating interleukin-10 level ( J:325487 )

• in LPS-treated mice

Genotype
MGI:7314912

cx2

• Allelic Composition: Igs2^{tm1(CAG-Ptgs2os)Scrp}/Igs2^{tm1(CAG-Ptgs2os)Scrp}; Ptgs2os^em1Scrp/Ptgs2os^em1Scrp
• Genetic Background: involves: C57BL/6

immune system

immune system phenotype ( J:325487 )

N • LPS-treated mice exhibit the same bronchoalveolar lavage fluid and serum levels of Ccl5 and Cxcl10 as similarly treated wild-type mice