All Phenotypes Ppp4r3a<em1Qili> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ppp4r3a^em1Qili
endonuclease-mediated mutation 1, Qiji Liu
MGI:7312039

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ppp4r3a^em1Qili/Ppp4r3a^em1Qili Emx1^tm1(cre)Krj/Emx1⁺	involves: 129S2/SvPas * C57BL/6J	MGI:7312047

Allelic Composition	Ppp4r3a^em1Qili/Ppp4r3a^em1Qili Emx1^tm1(cre)Krj/Emx1⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Krj mutation (2 available); any Emx1 mutation (30 available)
Ppp4r3a^em1Qili mutation (0 available); any Ppp4r3a mutation (67 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:326388 )

N	• mice exhibit normal spatial learning and memory skills

abnormal sucrose solution preference ( J:326388 )

• decreased sucrose preference

behavioral despair ( J:326388 )

• increased immobility time in a tail suspension test and open field test

increased anxiety-related response ( J:326388 )

• reduced exploration of open arms in an elevated plus maze

increased thigmotaxis ( J:326388 )

nervous system

decreased dendritic spine density ( J:326388 )

• in the hippocampus

abnormal miniature excitatory postsynaptic currents ( J:326388 )

• reduced frequency and amplitude

decreased neurotransmitter release ( J:326388 )

• decreased glutamate release

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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