Phenotypes associated with this allele

• Allele Symbol: Irgc^em1Osb
• Allele Name: endonuclease-mediated mutation 1, Research Institute for Microbial Diseases, Osaka University
• Allele ID: MGI:7311754
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Irgc^em1Osb/Irgc^em1Osb	B6;D2-Irgc^em1Osb/Osb	MGI:7311765

Genotype
MGI:7311765

hm1

• Allelic Composition: Irgc^em1Osb/Irgc^em1Osb
• Genetic Background: B6;D2-Irgc^em1Osb/Osb

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal sperm fibrous sheath morphology ( J:326368 )

• disorganized in the principal pieces with torn ribs that circumferentially connect longitudinal columns

short sperm flagellum ( J:326368 )

• without abnormalities in the midpiece

decreased sperm progressive motility ( J:326368 )

reduced male fertility ( J:326368 )

• severe subfertility

impaired fertilization ( J:326368 )

• spermatozoa fail to fertilize

• however, fertilization was removed by the removal of the extracellular matrix surrounding the oocyte even when cumulus cells are removed

impaired sperm penetration of zona pellucida ( J:326368 )

• due to impaired motility

cellular

abnormal sperm fibrous sheath morphology ( J:326368 )

• disorganized in the principal pieces with torn ribs that circumferentially connect longitudinal columns

short sperm flagellum ( J:326368 )

• without abnormalities in the midpiece

decreased sperm progressive motility ( J:326368 )