All Phenotypes Satb1<em1Zfa> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Satb1^em1Zfa
endonuclease-mediated mutation 1, Zusen Fan
MGI:7311696

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Satb1^em1Zfa/Satb1^em1Zfa	involves: C57BL/6	MGI:7311740
cn2	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0	involves: C57BL/6 * FVB	MGI:7311734
cn3	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Bptf^em1Zfa/Bptf^em1Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0	involves: C57BL/6 * FVB	MGI:7311735

Allelic Composition	Satb1^em1Zfa/Satb1^em1Zfa
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Satb1^em1Zfa mutation (0 available); any Satb1 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:259392 )

• mice die 4 weeks after birth

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• reduced absolute numbers of ILC3 cells due to impaired proliferation

Allelic Composition	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rik^em2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Satb1^em1Zfa mutation (0 available); any Satb1 mutation (48 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

immune system

increased susceptibility to bacterial infection ( J:259392 )

• in C. rodentium exposed mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:259392 )

• in C. rodentium exposed mice

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• greatly reduced absolute numbers of ILC3 cells due to reduced proliferation

Allelic Composition	A930024E05Rik^em2Zfa/A930024E05Rik^em2Zfa Bptf^em1Zfa/Bptf^em1Zfa Satb1^em1Zfa/Satb1^em1Zfa Tg(Rorc-cre)1Litt/0
Genetic Background	involves: C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rik^em2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Bptf^em1Zfa mutation (0 available); any Bptf mutation (157 available)
Satb1^em1Zfa mutation (0 available); any Satb1 mutation (48 available)
Tg(Rorc-cre)1Litt mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased common lymphocyte progenitor cell number ( J:259392 )

• reduced absolute numbers of ILC3 cells due to reduced proliferation

• however, overexpression of Zfp292 rescues ILC3 proliferation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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