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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		A930024E05Rikem2Zfa
endonuclease-mediated mutation 2, Zusen Fan
MGI:7311693
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+ 		involves: C57BL/6 * C57BL/10 * CBA/Ca MGI:7311733
cn2
 		A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Satb1em1Zfa/Satb1em1Zfa
Tg(Rorc-cre)1Litt/0 		involves: C57BL/6 * FVB MGI:7311734
cn3
 		A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Bptfem1Zfa/Bptfem1Zfa
Satb1em1Zfa/Satb1em1Zfa
Tg(Rorc-cre)1Litt/0 		involves: C57BL/6 * FVB MGI:7311735
cn4
 		A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Tg(Rorc-cre)1Litt/0 		involves: C57BL/6 * FVB MGI:7311736


Genotype
MGI:7311733
cn1
Allelic
Composition		 A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic
Background		 involves: C57BL/6 * C57BL/10 * CBA/Ca
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rikem2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Commd10Tg(Vav1-icre)A2Kio mutation (3 available); any Commd10 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:259392 )
N
• mice exhibit normal development of innate lymphoid cell progenitors

hematopoietic system
decreased common lymphocyte progenitor cell number ( J:259392 )
• reduced absolute numbers of ILC3 cells
• however, ILC1 and ILC2s numbers are normal




Genotype
MGI:7311734
cn2
Allelic
Composition		 A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Satb1em1Zfa/Satb1em1Zfa
Tg(Rorc-cre)1Litt/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rikem2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Satb1em1Zfa mutation (0 available); any Satb1 mutation (48 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
increased susceptibility to bacterial infection ( J:259392 )
• in C. rodentium exposed mice

hematopoietic system
decreased common lymphocyte progenitor cell number ( J:259392 )
• greatly reduced absolute numbers of ILC3 cells due to reduced proliferation




Genotype
MGI:7311735
cn3
Allelic
Composition		 A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Bptfem1Zfa/Bptfem1Zfa
Satb1em1Zfa/Satb1em1Zfa
Tg(Rorc-cre)1Litt/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rikem2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Bptfem1Zfa mutation (0 available); any Bptf mutation (157 available)
Satb1em1Zfa mutation (0 available); any Satb1 mutation (48 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased common lymphocyte progenitor cell number ( J:259392 )
• reduced absolute numbers of ILC3 cells due to reduced proliferation
• however, overexpression of Zfp292 rescues ILC3 proliferation




Genotype
MGI:7311736
cn4
Allelic
Composition		 A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Tg(Rorc-cre)1Litt/0
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
A930024E05Rikem2Zfa mutation (0 available); any A930024E05Rik mutation (85 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

immune system
abnormal interleukin secretion ( J:259392 )
• reduced IL22 secretion from intestinal lamina propria lymphocytes of C. rodentium exposed mice
increased susceptibility to bacterial infection ( J:259392 )
• C. rodentium-infected mice exhibit increased colon shortening, persistent intestinal damage, increased mortality, reduced IL22-secreting cells in the intestine, and IL22 secretion from intestinal lamina propria compared with control mice

hematopoietic system
decreased common lymphocyte progenitor cell number ( J:259392 )
• reduced absolute numbers of ILC3 cells due to reduced proliferation
• however, ILC1 and ILC2s numbers are normal




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory