Phenotypes associated with this allele

• Allele Symbol: Tmem163^em1Lwbch
• Allele Name: endonuclease-mediated mutation 1, Wei Li
• Allele ID: MGI:7310327
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem163^em1Lwbch/Tmem163^em1Lwbch	C57BL/6J-Tmem163^em1Lwbch	MGI:7310340

Genotype
MGI:7310340

hm1

• Allelic Composition: Tmem163^em1Lwbch/Tmem163^em1Lwbch
• Genetic Background: C57BL/6J-Tmem163^em1Lwbch

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:323340 )

N • mice exhibit normal platelet counts, mean platelet volume, and other hematological parameters

decreased platelet dense granule number ( J:323340 )

• absent

abnormal platelet physiology ( J:323340 )

• platelets exhibit significantly deficient uptake of mepacrine compared with wild-type cells

• platelets exposed to collagen or thrombin exhibit defective release of ATP compared with wild-type cells

• platelets exhibit defective zinc homeostasis compared with wild-type cells

decreased platelet aggregation ( J:323340 )

• in response to thrombin

homeostasis/metabolism

abnormal platelet physiology ( J:323340 )

• platelets exhibit significantly deficient uptake of mepacrine compared with wild-type cells

• platelets exposed to collagen or thrombin exhibit defective release of ATP compared with wild-type cells

• platelets exhibit defective zinc homeostasis compared with wild-type cells

decreased platelet aggregation ( J:323340 )

• in response to thrombin

increased bleeding time ( J:323340 )