Phenotypes associated with this allele

• Allele Symbol: Mir92b^em22Gpt
• Allele Name: endonuclease-mediated mutation 22, GemPharmatech Co., Ltd
• Allele ID: MGI:7302312
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir92b^em22Gpt/Mir92b^em22Gpt	involves: C57BL/6JGpt	MGI:7615228

Genotype
MGI:7615228

hm1

• Allelic Composition: Mir92b^em22Gpt/Mir92b^em22Gpt
• Genetic Background: involves: C57BL/6JGpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

muscle phenotype ( J:346344 )

♂N • no significant difference in muscle weights or gross morphology

♂N • forelimb grip strength is similar to controls

♂N • no difference in muscle triglyceride levels

abnormal skeletal muscle morphology ( J:346344 )

♂ • lower lactate levels after running to exhaustion in the gastrocnemius

increased skeletal muscle glycogen level ( J:346344 )

♂ • prior to exercise

increased skeletal muscle weight ( J:346344 )

♂ • increased weight of the gastrocnemius and tibialis anterior in mice on a high fat diet and treated with streptozotocin

homeostasis/metabolism

improved glucose tolerance ( J:346344 )

♂ • in mice on a high fat diet and treated with streptozotocin

increased skeletal muscle glycogen level ( J:346344 )

♂ • prior to exercise

increased insulin sensitivity ( J:346344 )

♂ • reduced insulin resistance in mice on a high fat diet and treated with streptozotocin compared to similarly treated wild-type controls

enhanced exercise endurance ( J:346344 )

♂ • enhanced exhaustive running time and maximum running distance in a high-intensity treadmill exercise regimen

growth/size/body

decreased body fat mass ( J:346344 )

♂ • in mice on a high fat diet and treated with streptozotocin fat mass to body weight is decreased

increased lean body mass ( J:346344 )

♂ • in mice on a high fat diet and treated with streptozotocin lean mass to body weight is increased

adipose tissue

decreased body fat mass ( J:346344 )

♂ • in mice on a high fat diet and treated with streptozotocin fat mass to body weight is decreased