Phenotypes associated with this allele

• Allele Symbol: Kdm7a^em1Gpt
• Allele Name: endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• Allele ID: MGI:7301211
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kdm7a^em1Gpt/Kdm7a^em1Gpt Sp7^tm1(icre)Bcgen/Sp7^+	involves: C57BL/6 * C57BL/6JGpt	MGI:8240381

Genotype
MGI:8240381

cn1

• Allelic Composition: Kdm7a^em1Gpt/Kdm7a^em1Gpt; Sp7^{tm1(icre)Bcgen}/Sp7⁺
• Genetic Background: involves: C57BL/6 * C57BL/6JGpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased bone marrow adipose tissue amount ( J:366478 )

• the number and area of adipocytes in tibial marrow are reduced by 60 and 68%, respectively in females and by 73 and 81%, respectively, in males

enhanced osteoblast differentiation ( J:366478 )

• following osteogenic treatment, osteoblast differentiation from bone marrow stromal cells is increased

• differentiation potential of calvarial pre-osteoblastic cells toward osteoblasts is enhanced

abnormal osteoclast differentiation ( J:366478 )

• osteoclast formation from osteoclast precursor cells is suppressed

• under osteoclastogenic induction, bone marrow cells form fewer osteoclasts

• when co-cultured with wild-type bone marrow macrophages, mutant bone marrow stromal cells show suppressed osteoclast formation

decreased osteoclast cell number ( J:366478 )

• number of osteoclasts is reduced by 58% in females and by 42% in males

increased bone mineral content ( J:366478 )

• proximal tibial metaphysis trabecular bone mineral content/total volume is increased by 122% in 24-week-old mice

• trabecular bone mineral content/total volume is increased in lumbar vertebrae

increased osteoblast cell number ( J:366478 )

• alkaline phosphatase-positive osteoblasts are increased by 46% in females and by 62% in males

abnormal trabecular bone morphology ( J:366478 )

• proximal tibial metaphysis trabecular bone mineral content/total volume is increased by 122% in 24-week-old mice

increased trabecular bone volume ( J:366478 )

• proximal tibial metaphysis trabecular bone volume/total volume is increased by 96% in 24-week-old mice

• trabecular bone volume/total volume is increased in lumbar vertebrae

increased bone trabecula number ( J:366478 )

• proximal tibial metaphysis trabecular number is slightly increased in 12-week-old mice and is increased by 55% in 24-week-old mice

• trabecular number is increased in lumbar vertebrae

decreased bone trabecular spacing ( J:366478 )

• proximal tibial metaphysis trabecular spacing is slightly decreased in both males and females at 12 weeks of age and is reduced by 37% in 24-week-old females

• trabecular spacing is decreased in lumbar vertebrae

increased trabecular bone mass ( J:366478 )

• 24-week-old mice exhibit greater cancellous bone mass in the proximal metaphysis of tibiae

• mice exhibit prevention of ovariectomy-induced bone loss

increased bone mineralization ( J:366478 )

• mineral apposition rate, mineralizing surface/bone surface and bone formation rate/bone surface are increased in females

increased bone ossification ( J:366478 )

• serum level of procollagen type I N-terminal peptide (PINP), a bone formation marker, is increased in both males and females

decreased bone resorption ( J:366478 )

• serum level of C-terminal telopeptide of type I collagen, a bone resorption maker, is decreased in both males and females indicating reduced bone resorption

adipose tissue

decreased bone marrow adipose tissue amount ( J:366478 )

• the number and area of adipocytes in tibial marrow are reduced by 60 and 68%, respectively in females and by 73 and 81%, respectively, in males

abnormal fat cell differentiation ( J:366478 )

• following adipogenic treatment, adipocyte differentiation from bone marrow stromal cells is impaired

• differentiation potential of calvarial pre-osteoblastic cells toward adipocytes is suppressed

cellular

abnormal fat cell differentiation ( J:366478 )

• following adipogenic treatment, adipocyte differentiation from bone marrow stromal cells is impaired

• differentiation potential of calvarial pre-osteoblastic cells toward adipocytes is suppressed

enhanced osteoblast differentiation ( J:366478 )

• following osteogenic treatment, osteoblast differentiation from bone marrow stromal cells is increased

• differentiation potential of calvarial pre-osteoblastic cells toward osteoblasts is enhanced

abnormal osteoclast differentiation ( J:366478 )

• osteoclast formation from osteoclast precursor cells is suppressed

• under osteoclastogenic induction, bone marrow cells form fewer osteoclasts

• when co-cultured with wild-type bone marrow macrophages, mutant bone marrow stromal cells show suppressed osteoclast formation

hematopoietic system

abnormal osteoclast differentiation ( J:366478 )

• osteoclast formation from osteoclast precursor cells is suppressed

• under osteoclastogenic induction, bone marrow cells form fewer osteoclasts

• when co-cultured with wild-type bone marrow macrophages, mutant bone marrow stromal cells show suppressed osteoclast formation

decreased osteoclast cell number ( J:366478 )

• number of osteoclasts is reduced by 58% in females and by 42% in males

homeostasis/metabolism

decreased tumor necrosis factor (ligand) superfamily member 11 level ( J:366478 )

• serum levels of RANKL are lower

immune system

abnormal osteoclast differentiation ( J:366478 )

• osteoclast formation from osteoclast precursor cells is suppressed

• under osteoclastogenic induction, bone marrow cells form fewer osteoclasts

• when co-cultured with wild-type bone marrow macrophages, mutant bone marrow stromal cells show suppressed osteoclast formation

decreased osteoclast cell number ( J:366478 )

• number of osteoclasts is reduced by 58% in females and by 42% in males