Phenotypes associated with this allele

• Allele Symbol: Cep78^em2Gpt
• Allele Name: endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
• Allele ID: MGI:7296812
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cep78^em2Gpt/Cep78^em2Gpt	C57BL/6JGpt-Cep78^em2Gpt	MGI:7444965

Genotype
MGI:7444965

hm1

• Allelic Composition: Cep78^em2Gpt/Cep78^em2Gpt
• Genetic Background: C57BL/6JGpt-Cep78^em2Gpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

oligozoospermia ( J:333155 )

♂

teratozoospermia ( J:333155 )

♂

abnormal sperm flagellum morphology ( J:333155 )

♂

abnormal sperm axoneme morphology ( J:333155 )

♂ • abnormal or absent

abnormal sperm midpiece morphology ( J:333155 )

♂ • with disorganized microtubule doublets and missing central pairs

absent sperm flagellum ( J:333155 )

♂ • in some sperm

short sperm flagellum ( J:333155 )

♂

abnormal sperm head morphology ( J:333155 )

♂ • amorphous

asthenozoospermia ( J:333155 )

♂

male infertility ( J:333155 )

♂ • infertility could not be overcome with intracytoplasmic sperm injection

decreased fertilization frequency ( J:333155 )

♂ • fertilization phenotype could not be overcome with intracytoplasmic sperm injection

vision/eye

short photoreceptor inner segment ( J:333155 )

• in 6-month-old mice

short photoreceptor outer segment ( J:333155 )

• in 6-month-old mice

abnormal retina cone cell outer segment morphology ( J:333155 )

• decreased number

retina degeneration ( J:333155 )

• grayish retinal pigment mottling at 3 months of age resembling retinitis pigmentosa

decreased a-wave amplitude ( J:333155 )

• in dark adapted mice at 6 months of age

decreased b-wave amplitude ( J:333155 )

• reduced following light adaptation at 3 and 6 months of age

• slightly in dark adapted mice at 3 and 6 months of age

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:333155 )

• moderate to severe sensorineural hearing loss at 3 months of age with increased hearing loss at 6 months of age

abnormal distortion product otoacoustic emission ( J:333155 )

• at 3 months of age

absent distortion product otoacoustic emissions ( J:333155 )

• at 6 months of age

nervous system

short photoreceptor inner segment ( J:333155 )

• in 6-month-old mice

short photoreceptor outer segment ( J:333155 )

• in 6-month-old mice

abnormal retina cone cell outer segment morphology ( J:333155 )

• decreased number

cellular

oligozoospermia ( J:333155 )

♂

teratozoospermia ( J:333155 )

♂

abnormal sperm flagellum morphology ( J:333155 )

♂

abnormal sperm axoneme morphology ( J:333155 )

♂ • abnormal or absent

abnormal sperm midpiece morphology ( J:333155 )

♂ • with disorganized microtubule doublets and missing central pairs

absent sperm flagellum ( J:333155 )

♂ • in some sperm

short sperm flagellum ( J:333155 )

♂

abnormal sperm head morphology ( J:333155 )

♂ • amorphous

asthenozoospermia ( J:333155 )

♂