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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccdc65em11Gpt
endonuclease-mediated mutation 11, GemPharmatech Co., Ltd
MGI:7296395
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccdc65em11Gpt/Ccdc65em11Gpt C57BL/6J-Ccdc65em11Gpt MGI:7606224
ht2
 		Ccdc65em11Gpt/Ccdc65+ C57BL/6J-Ccdc65em11Gpt MGI:7606229


Genotype
MGI:7606224
hm1
Allelic
Composition		 Ccdc65em11Gpt/Ccdc65em11Gpt
Genetic
Background		 C57BL/6J-Ccdc65em11Gpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc65em11Gpt mutation (0 available); any Ccdc65 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:327251 )
• all mice die within 3 weeks after birth, possibly due to hydrocephalus
prenatal lethality, incomplete penetrance ( J:327251 )
• birth rate is lower than that expected from Mendelian ratios

growth/size/body
megacephaly ( J:327251 )
• mice exhibit a larger head size than wild-type or heterozygous mice
decreased body size ( J:327251 )
postnatal growth retardation ( J:327251 )
• mice develop slowly relative to wild-type or heterozygous mice

nervous system
abnormal brain morphology ( J:327251 )
• the craniocerebral diameter ratio is significantly lower than that in wild-type or heterozygous mice, and brain tissue appears sunken rather than full
enlarged lateral ventricles ( J:327251 )
• mice show significantly larger lateral ventricles than wild-type or heterozygous mice
abnormal cerebrospinal fluid flow ( J:327251 )
• mice exhibit disordered circulation of cerebrospinal fluid




Genotype
MGI:7606229
ht2
Allelic
Composition		 Ccdc65em11Gpt/Ccdc65+
Genetic
Background		 C57BL/6J-Ccdc65em11Gpt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccdc65em11Gpt mutation (0 available); any Ccdc65 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:327251 )
• following weekly i.p. injections with urethane (1 g/kg) for 20 weeks, the average number of lung tumor nodules and average area of adenocarcinomas/adenomas is significantly greater than in similarly treated wild-type controls

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:327251 )
• following weekly i.p. injections with urethane (1 g/kg) for 20 weeks, the average number of lung tumor nodules and average area of adenocarcinomas/adenomas is significantly greater than in similarly treated wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory