Phenotypes associated with this allele

• Allele Symbol: Ccdc65^em11Gpt
• Allele Name: endonuclease-mediated mutation 11, GemPharmatech Co., Ltd
• Allele ID: MGI:7296395
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ccdc65^em11Gpt/Ccdc65^em11Gpt	C57BL/6J-Ccdc65^em11Gpt	MGI:7606224
ht2	Ccdc65^em11Gpt/Ccdc65^+	C57BL/6J-Ccdc65^em11Gpt	MGI:7606229

Genotype
MGI:7606224

hm1

• Allelic Composition: Ccdc65^em11Gpt/Ccdc65^em11Gpt
• Genetic Background: C57BL/6J-Ccdc65^em11Gpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:327251 )

• all mice die within 3 weeks after birth, possibly due to hydrocephalus

prenatal lethality, incomplete penetrance ( J:327251 )

• birth rate is lower than that expected from Mendelian ratios

growth/size/body

megacephaly ( J:327251 )

• mice exhibit a larger head size than wild-type or heterozygous mice

decreased body size ( J:327251 )

postnatal growth retardation ( J:327251 )

• mice develop slowly relative to wild-type or heterozygous mice

nervous system

abnormal brain morphology ( J:327251 )

• the craniocerebral diameter ratio is significantly lower than that in wild-type or heterozygous mice, and brain tissue appears sunken rather than full

hydrocephaly ( J:327251 )

enlarged lateral ventricles ( J:327251 )

• mice show significantly larger lateral ventricles than wild-type or heterozygous mice

abnormal cerebrospinal fluid flow ( J:327251 )

• mice exhibit disordered circulation of cerebrospinal fluid

Genotype
MGI:7606229

ht2

• Allelic Composition: Ccdc65^em11Gpt/Ccdc65⁺
• Genetic Background: C57BL/6J-Ccdc65^em11Gpt

neoplasm

increased incidence of tumors by chemical induction ( J:327251 )

• following weekly i.p. injections with urethane (1 g/kg) for 20 weeks, the average number of lung tumor nodules and average area of adenocarcinomas/adenomas is significantly greater than in similarly treated wild-type controls

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:327251 )

• following weekly i.p. injections with urethane (1 g/kg) for 20 weeks, the average number of lung tumor nodules and average area of adenocarcinomas/adenomas is significantly greater than in similarly treated wild-type controls