All Phenotypes Tmco1<tm1Tsta> MGI Mouse

decreased body weight ( J:268917 )

• at 6-7 months of age, body weight is ~80% of that in wild-type females

oocyte degeneration ( J:268917 )

• at 1 month of age, degraded oocytes accumulate in the ovaries

increased granulosa cell apoptosis ( J:268917 )

• granulosa cells display increased endoplasmic reticulum (ER) stress-mediated apoptosis

abnormal ovary morphology ( J:268917 )

• at 6 months of age, ovaries appear flattened

absent corpus luteum ( J:268917 )

• at 6 months of age, no corpora lutea structures are observed

• however, corpora lutea are detectable at 7 weeks of age

decreased primary ovarian follicle number ( J:268917 )

• at 7 weeks of age, the average number of primary follicles per ovary is about three quarters of that in wild-type controls

• at 16 weeks of age, the number of primary follicles is significantly lower than in wild-type controls

decreased primordial ovarian follicle number ( J:268917 )

• at P7, the number of primordial follicles is significantly decreased, whereas the numbers of primary and secondary follicles are relatively normal

• at 7 weeks of age, the average number of primordial follicles per ovary is ~1000 relative to >1500 in wild-type controls

• at 10 weeks of age, only a few primordial follicles are detected, indicating a reduced primordial follicle pool

decreased secondary ovarian follicle number ( J:268917 )

• at 7 and 16 weeks of age, the average number of secondary follicles per ovary is significantly lower than in wild-type controls

absent ovarian follicles ( J:268917 )

• at 6 months of age, no obvious ovarian follicle structures are observed, except for some cells remnants probably reflecting luteolysis

increased atretic ovarian follicle number ( J:268917 )

• at 1 month of age, the number of atretic follicles per ovary is significantly higher than in wild-type controls

impaired ovarian folliculogenesis ( J:268917 )

• at P7 and at 7 and 16 weeks of age, the total number of ovarian follicles per ovary is significantly lower than in wild-type controls

• by 16 weeks of age, ovaries contain markedly reduced numbers of all stages of ovarian follicles; the % of primary and secondary follicles are severely reduced

• a progressive reduction in total number of ovarian follicles per ovary is observed from P4 to P157

• however, the number of germ cells is grossly normal at P2

small ovary ( J:268917 )

• at 6 months of age, ovaries are smaller than in wild-type females

decreased ovary weight ( J:268917 )

• at 6-7 months of age, ovarian weight is ~80% of that in wild-type females

• however, the ovary weight to body weight ratio is similar to that in wild-type females

premature ovarian failure ( J:268917 )

• females show premature depletion of primordial follicle pool and a gradual loss of ovarian follicles of all stages, indicating premature ovarian failure

decreased superovulation rate ( J:268917 )

• after superovulation induction in 3-month-old females, the number of ovulated MII stage eggs per mouse is significantly lower than in superovulated wild-type females

reduced female fertility ( J:268917 )

• when 7-week-old females are mated with wild-type males for ~4 months, the total number of live pups delivered is significantly lower than in control females (277 versus 647), whereas the total number of dead pups is increased (38 versus 5)

decreased litter size ( J:268917 )

• females produce significantly fewer pups per litter than wild-type females

increased granulosa cell apoptosis ( J:268917 )

• granulosa cells display increased endoplasmic reticulum (ER) stress-mediated apoptosis

abnormal ovary morphology ( J:268917 )

• at 6 months of age, ovaries appear flattened

absent corpus luteum ( J:268917 )

• at 6 months of age, no corpora lutea structures are observed

• however, corpora lutea are detectable at 7 weeks of age

decreased primary ovarian follicle number ( J:268917 )

• at 7 weeks of age, the average number of primary follicles per ovary is about three quarters of that in wild-type controls

• at 16 weeks of age, the number of primary follicles is significantly lower than in wild-type controls

decreased primordial ovarian follicle number ( J:268917 )

• at P7, the number of primordial follicles is significantly decreased, whereas the numbers of primary and secondary follicles are relatively normal

• at 7 weeks of age, the average number of primordial follicles per ovary is ~1000 relative to >1500 in wild-type controls

• at 10 weeks of age, only a few primordial follicles are detected, indicating a reduced primordial follicle pool

decreased secondary ovarian follicle number ( J:268917 )

• at 7 and 16 weeks of age, the average number of secondary follicles per ovary is significantly lower than in wild-type controls

absent ovarian follicles ( J:268917 )

• at 6 months of age, no obvious ovarian follicle structures are observed, except for some cells remnants probably reflecting luteolysis

increased atretic ovarian follicle number ( J:268917 )

• at 1 month of age, the number of atretic follicles per ovary is significantly higher than in wild-type controls

impaired ovarian folliculogenesis ( J:268917 )

• at P7 and at 7 and 16 weeks of age, the total number of ovarian follicles per ovary is significantly lower than in wild-type controls

• by 16 weeks of age, ovaries contain markedly reduced numbers of all stages of ovarian follicles; the % of primary and secondary follicles are severely reduced

• a progressive reduction in total number of ovarian follicles per ovary is observed from P4 to P157

• however, the number of germ cells is grossly normal at P2

small ovary ( J:268917 )

• at 6 months of age, ovaries are smaller than in wild-type females

decreased ovary weight ( J:268917 )

• at 6-7 months of age, ovarian weight is ~80% of that in wild-type females

• however, the ovary weight to body weight ratio is similar to that in wild-type females

premature ovarian failure ( J:268917 )

• females show premature depletion of primordial follicle pool and a gradual loss of ovarian follicles of all stages, indicating premature ovarian failure

homeostasis/metabolism phenotype ( J:268917 )

N	• at 16-22 weeks of age, females show normal serum testosterone and progesterone levels relative to wild-type controls

decreased circulating estradiol level ( J:268917 )

• at 16-22 weeks of age, female serum estradiol (E2) levels are significantly lower than in wild-type controls

increased circulating follicle stimulating hormone level ( J:268917 )

• at 16-22 weeks of age, female serum FSH levels are significantly higher than in wild-type controls

increased circulating luteinizing hormone level ( J:268917 )

• at 16-22 weeks of age, female serum LH levels are significantly higher than in wild-type controls

abnormal calcium ion homeostasis ( J:268917 )

• granulosa cells exhibit supernormal Ca²⁺ signaling and an overloaded endoplasmic reticulum (ER) Ca²⁺ store

• although spontaneous Ca²⁺ oscillation pattern is altered, ER Ca²⁺ stores of germinal vesicle (GV) stage oocytes and MII-arrested eggs are normal

oocyte degeneration ( J:268917 )

• at 1 month of age, degraded oocytes accumulate in the ovaries

increased granulosa cell apoptosis ( J:268917 )

• granulosa cells display increased endoplasmic reticulum (ER) stress-mediated apoptosis

increased endoplasmic reticulum stress ( J:268917 )

• granulosa cells display increased ER stress-mediated apoptosis

oxidative stress ( J:268917 )

• granulosa cells exhibit an increased cellular reactive oxygen species (ROS) level

premature ovarian failure ( J:268917 )

• females show premature depletion of primordial follicle pool and a gradual loss of ovarian follicles of all stages, indicating premature ovarian failure

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

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