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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atp23em1Cya
endonuclease-mediated mutation 1, Cyagen
MGI:7294249
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atp23em1Cya/Atp23em1Cya involves: C57BL/6N MGI:7294251


Genotype
MGI:7294251
hm1
Allelic
Composition
Atp23em1Cya/Atp23em1Cya
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp23em1Cya mutation (0 available); any Atp23 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• pups are present in expected numbers at E15.5 and E18.5, but all die between E18.5 and 6 hours after birth

respiratory system
• at the late canalicular stage (E17.5) lungs show a dense appearance and little saccular expansion
• at E18.5 lungs display decreased expression of type I and type II alveolar epithelial cell differentiation markers
• increased thickness of the mesenchymal septa at E18.5
• at E18.5
• reduced amounts of alveoli at E18.5
• at E18.5
• reduced interalveolar space and decrease in the number of distal alveoli
• no tracheal dysfunction is seen
• at E18.5
• decrease in the amount of surfactant-associated proteins in the lungs at E18.5

growth/size/body
• at E15.5 and E18.5

integument
• appear a little whiter than litter-mates at E15.5 and E18.5





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory