Analysis Tools|
Allele Symbol Allele Name Allele ID |
Sec16aem1Smoc endonuclease-mediated mutation 1, Shanghai Model Organisms Center MGI:7292204 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• isolated cells show increased intracellular vacuolization and visible ER dilations with protein overload
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• cultured primary pancreatic acinar cells show higher levels of ER stress even without viral infection and this is further exacerbated with AMY2A-lentivirus infection or cerulein-stimulation
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• decrease in AMY2A-lentivirus induced amylase secretion in cultured primary pancreatic acinar cells
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• exacerbated cerulein-induced acute pancreatitis with increased pancreatic/body weight ratio, higher serum amylase levels and more severe histology scores
• however, no significant pancreatic abnormalities are detected at baseline
• in a chronic pancreatitis model cerulein-treated mice show more severe exocrine pancreatic atrophy with higher levels of collagen deposition and fibrosis and increased infiltration of inflammatory cells compared to similarly treated controls
• in a chronic pancreatitis model cerulein-treated mice show increased proliferation of pancreatic duct cells
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• exacerbated cerulein-induced acute pancreatitis with increased pancreatic/body weight ratio, higher serum amylase levels and more severe histology scores
• however, no significant pancreatic abnormalities are detected at baseline
• in a chronic pancreatitis model cerulein-treated mice show more severe exocrine pancreatic atrophy with higher levels of collagen deposition and fibrosis and increased infiltration of inflammatory cells compared to similarly treated controls
• in a chronic pancreatitis model cerulein-treated mice show increased proliferation of pancreatic duct cells
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• isolated pancreatic cells show visible ER dilations with protein overload
|
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• isolated cells show increased intracellular vacuolization and visible ER dilations with protein overload
|
|
• cultured primary pancreatic acinar cells show higher levels of ER stress even without viral infection and this is further exacerbated with AMY2A-lentivirus infection or cerulein-stimulation
|
|
• decrease in AMY2A-lentivirus induced amylase secretion in cultured primary pancreatic acinar cells
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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