Phenotypes associated with this allele

• Allele Symbol: Igfbp6^em2Smoc
• Allele Name: endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• Allele ID: MGI:7290365
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igfbp6^em2Smoc/Igfbp6^em2Smoc	C57BL/6JSmoc-Igfbp6^em2Smoc	MGI:8278434

Genotype
MGI:8278434

hm1

• Allelic Composition: Igfbp6^em2Smoc/Igfbp6^em2Smoc
• Genetic Background: C57BL/6JSmoc-Igfbp6^em2Smoc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased susceptibility to atherosclerosis ( J:375214 )

♂ • 8-week-old male mice infected with an adenovirus expressing Pcsk9 with a D377Y mutation to reduce LDLR protein levels in the liver and induce atherosclerosis and fed with a high-cholesterol diet (HCD) for 2 weeks and then subjected to partial carotid ligation surgery and continued HCD feeding show increased area of atherosclerotic plaques in the left carotid artery

♂ • however, these mice show no differences in levels of plasma total cholesterol, triglycerides, high-density lipoprotein cholesterol, low density lipoprotein cholesterol, aspartate aminotransferase or alanine aminotransferase