Analysis Tools
cardiovascular system
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• both male and female mice infected with an adenovirus expressing the gain-of-function murine Pcsk9 with a D377Y mutation to reduce LDLR protein levels in the liver and induce atherosclerosis and fed with a high-cholesterol diet (HCD) for 12 weeks show an increase in atherosclerotic plaque area in aorta, aortic sinus, and in the branchiocephalic artery
• collagen content and alpha-SMA expression in plaques is decreased and CD68+ macrophage content is increased in aortic plaques of these atherosclerosis-induced and HCD-fed mice
• mice with induced atherosclerosis and fed a high-cholesterol diet exhibit an aortic root with increased lesional necrotic core size
• however, these mice show no differences in body weight, blood glucose or levels of plasma total cholesterol, triglycerides, high-density lipoprotein cholesterol, low density lipoprotein cholesterol, aspartate aminotransferase or alanine aminotransferase
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cellular
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• males injected with TNF into the peritoneal cavity at 4-6 weeks of age to induce leukocyte adhesion show increased number of rolling and adhering leukocytes in the mesenteric vessels and slowed movement of leukocytes
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hematopoietic system
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• males injected with TNF into the peritoneal cavity at 4-6 weeks of age to induce leukocyte adhesion show increased number of rolling and adhering leukocytes in the mesenteric vessels and slowed movement of leukocytes
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immune system
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• males injected with TNF into the peritoneal cavity at 4-6 weeks of age to induce leukocyte adhesion show increased number of rolling and adhering leukocytes in the mesenteric vessels and slowed movement of leukocytes
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