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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Matcap1em1Nki
endonuclease-mediated mutation 1, The Netherlands Cancer Institute
MGI:7287849
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Matcap1em1Nki/Matcap1em1Nki Not Specified MGI:7293340
cx2
 		Matcap1em1Nki/Matcap1em1Nki
Svbpem1Mjom/Svbpem1Mjom 		involves: C57BL/6 MGI:7293341


Genotype
MGI:7293340
hm1
Allelic
Composition		 Matcap1em1Nki/Matcap1em1Nki
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Matcap1em1Nki mutation (0 available); any Matcap1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased brain size ( J:325393 )
• decreased volume
small olfactory bulb ( J:325393 )
• decreased volume
small cerebellum ( J:325393 )
• decreased volume




Genotype
MGI:7293341
cx2
Allelic
Composition		 Matcap1em1Nki/Matcap1em1Nki
Svbpem1Mjom/Svbpem1Mjom
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Matcap1em1Nki mutation (0 available); any Matcap1 mutation (16 available)
Svbpem1Mjom mutation (0 available); any Svbp mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal nest building behavior ( J:325393 )
• mice fail to build nests unlike wild-type mice

nervous system
decreased neuronal precursor proliferation ( J:325393 )
• at E14.5 in the ventricular and subventricular zone
decreased brain size ( J:325393 )
• more severe than in single homozygotes
small olfactory bulb ( J:325393 )
• more severe than in single homozygotes
small cerebellum ( J:325393 )
• more severe than in single homozygotes

cellular
decreased neuronal precursor proliferation ( J:325393 )
• at E14.5 in the ventricular and subventricular zone




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory