Phenotypes associated with this allele

• Allele Symbol: Rbpms^em1Eno
• Allele Name: endonuclease-mediated mutation 1, Eric N Olson
• Allele ID: MGI:7287467
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rbpms^em1Eno/Rbpms^em1Eno	involves: C3H * C57BL/6	MGI:7287471

Genotype
MGI:7287471

hm1

• Allelic Composition: Rbpms^em1Eno/Rbpms^em1Eno
• Genetic Background: involves: C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:324468 )

• all mice die by P4

cardiovascular system

patent ductus arteriosus ( J:324468 )

myocardial ventricular hypertrabeculation ( J:324468 )

• hypertrabeculated ventricles at P1

• increased thickness at the level of the papillary muscle

thin ventricle myocardium compact layer ( J:324468 )

• at P1

• at the level of the papillary muscle

decreased fetal cardiomyocyte number ( J:324468 )

• reduced cardiomyocytes numbers due to disrupted cardiomyocyte cytokinesis and premature binucleation

double outlet right ventricle ( J:324468 )

• in 7 of 12 pups

thin interventricular septum ( J:324468 )

ventricular septal defect ( J:324468 )

• in 7 of 12 pups

pulmonary alveolar hemorrhage ( J:324468 )

• severe and broad

decreased cardiac muscle contractility ( J:324468 )

• decreased fraction shortening and ejection fraction between P1 and P3

cardiomyopathy ( J:324468 )

• noncompaction cardiomyopathy

respiratory system

respiratory system phenotype ( J:324468 )

N • lung morphology is normal after birth

pulmonary alveolar hemorrhage ( J:324468 )

• severe and broad

homeostasis/metabolism

cyanosis ( J:324468 )

• before death

cellular

patent ductus arteriosus ( J:324468 )

behavior/neurological

behavior/neurological phenotype ( J:324468 )

N • dead mice have milk in their stomachs

muscle

myocardial ventricular hypertrabeculation ( J:324468 )

• hypertrabeculated ventricles at P1

• increased thickness at the level of the papillary muscle

thin ventricle myocardium compact layer ( J:324468 )

• at P1

• at the level of the papillary muscle

decreased cardiac muscle contractility ( J:324468 )

• decreased fraction shortening and ejection fraction between P1 and P3

cardiomyopathy ( J:324468 )

• noncompaction cardiomyopathy