Phenotypes associated with this allele

• Allele Symbol: Or2l13b^em1Scjc
• Allele Name: endonuclease-mediated mutation 1, Scott J Cameron
• Allele ID: MGI:7281119
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Or2l13b^em1Scjc/Or2l13b^em1Scjc	FVB/NTac-Or2l13b^em1Scjc	MGI:7281121

Genotype
MGI:7281121

hm1

• Allelic Composition: Or2l13b^em1Scjc/Or2l13b^em1Scjc
• Genetic Background: FVB/NTac-Or2l13b^em1Scjc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal platelet morphology ( J:324598 )

• platelets exhibit enhanced thrombotic granule content

• however, platelet count, WBC count, and hemoglobin concentration at baseline or after AAA induction are not affected

abnormal platelet activation ( J:324598 )

• isolated platelets show increased reactivity when stimulated with thrombin ex vivo

homeostasis/metabolism

abnormal platelet activation ( J:324598 )

• isolated platelets show increased reactivity when stimulated with thrombin ex vivo

abnormal enzyme/coenzyme activity ( J:324598 )

• mice show augmented aortic MMP2 activity

abnormal response to injury ( J:324598 )

• in an abdominal aortic aneurysm (AAA) model, the magnitude of disturbed flow (D-flow) in aneurysmal arterial segments, the rate of aortic growth, and incidence of aortic rupture are increased