Phenotypes associated with this allele

• Allele Symbol: Aff3^em1Andg
• Allele Name: endonuclease-mediated mutation 1, Guillaume Andrey
• Allele ID: MGI:7266365
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aff3^em1Andg/Aff3^em1Andg	chimera involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1	MGI:7266687
ht2	Aff3^em1Andg/Aff3^+	involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1	MGI:7266717

Genotype
MGI:7266687

hm1

• Allelic Composition: Aff3^em1Andg/Aff3^em1Andg
• Genetic Background: chimera involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal fibula morphology ( J:317476 )

• severely hypoplastic in 12 of 12 mice at E18.5

abnormal tibia morphology ( J:317476 )

• triangular shape in 12 of 12 mice at E18.5

decreased length of long bones ( J:317476 )

• mesomelic dysplasia seen in 12 of 12 mice at E18.5

abnormal pelvic girdle bone morphology ( J:317476 )

• hypoplastic pelvis in 12 of 12 mice

delayed bone ossification ( J:317476 )

• in bones of the skull

nervous system

abnormal nervous system physiology ( J:317476 )

• neurological dysfunction

digestive/alimentary system

abnormal intestine morphology ( J:317476 )

• intestinal prolapse in 10 of 12 mice

growth/size/body

decreased fetal size ( J:317476 )

• at E18.5

limbs/digits/tail

polydactyly ( J:317476 )

• of the feet in 5 of 12 mice at E18.5

abnormal fibula morphology ( J:317476 )

• severely hypoplastic in 12 of 12 mice at E18.5

abnormal tibia morphology ( J:317476 )

• triangular shape in 12 of 12 mice at E18.5

craniofacial

abnormal craniofacial morphology ( J:317476 )

• in 12 of 12 mice at E14.5 and E18.5

Genotype
MGI:7266717

ht2

• Allelic Composition: Aff3^em1Andg/Aff3⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCrl * CD-1

mortality/aging

prenatal lethality ( J:317476 )

• no heterozygous offspring are produced by high proportion chimeras suggesting prenatal lethality