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Allele Symbol Allele Name Allele ID |
Palmtm1.2Kili targeted mutation 1.2, Manfred W Kilimann MGI:6883588 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are healthy, fertile and overtly normal and show normal development of the lymphatic network in the tail and intestinal villi after birth; adult mice exhibit normal lymphatic vessel structure and physiological function with no signs of lymphedema
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 12-week-old mice show a significant decrease in the Lyve-1+ lymphatic coverage of pancreatic tumors relative to double transgenic mice that are wild-type for Palm, indicating impaired tumor-associated lymphangiogenesis
• however, no changes in the number of pancreatic tumors, tumor volume, or intratumoral CD31+ blood microvessel density are observed relative to double transgenic mice wild-type for Palm
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 4-week-old mice show an increase in peri-insular lymphangiogenesis and Lyve-1+ lymphatic vessel density in the periphery of islets of Langerhans that is comparable to that seen in non-tumorigenic Tg(Ins2-VEGFC)#Pepr transgenic mice, consistent with de novo lymphangiogenesis
• however, no increase in CD31+ blood microvessel density is observed within islets, similar to Tg(Ins2-VEGFC)#Pepr mice, suggesting normal angiogenesis
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/28/2024 MGI 6.13 |
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