Phenotypes associated with this allele

• Allele Symbol: Slc1a7^em1Fmul
• Allele Name: endonuclease-mediated mutation 1, Frank Muller
• Allele ID: MGI:6867259
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc1a7^em1Fmul/Slc1a7^em1Fmul	B6J.B6N-Slc1a7^em1Fmul	MGI:7517229

Genotype
MGI:7517229

hm1

• Allelic Composition: Slc1a7^em1Fmul/Slc1a7^em1Fmul
• Genetic Background: B6J.B6N-Slc1a7^em1Fmul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:320020 )

N • no gross morphological changes in the retina

abnormal electroretinogram waveform feature ( J:320020 )

• temporal resolution is significantly compromised with half-maximal resolution at 10Hz compared to 14 Hz in wild-type mice in a flicker stimulus assay

abnormal eye electrophysiology ( J:320020 )

• at 16Hz flicker stimulus is not well resolved in recordings of spiking behavior of ON-ganglion cells unlike in wild-type mice

• however, resolution at 2 and 8 Hz resolution is seen in both mutant and wild-type mice

• impact on temporal resolution depends on stimulus intensity with differences seen for bright light