All Phenotypes Asrgl1<em1Xjz> MGI Mouse

increased retina apoptosis ( J:320011 )

• TUNEL assays showed increased retina apoptosis at 15 months of age; TUNEL+ cells are mostly found in the outer nuclear layer (ONL), indicating continuous photoreceptor cell death

thin retina inner nuclear layer ( J:320011 )

• inner nuclear layer (INL) thickness is normal at 9 months but slightly decreased at 15 months of age

thin retina outer nuclear layer ( J:320011 )

• outer nuclear layer (ONL) thickness is progressively reduced starting at 9 months of age and ONL is drastically thinner by 15 months age

abnormal retina photoreceptor layer morphology ( J:320011 )

• thickness of the photoreceptor layer (inner segment + outer segment) is progressively decreased starting at 9 months of age and drastically reduced by 15 months age

decreased retina cone cell number ( J:320011 )

• number of cone cells is decreased at 12 months and drastically reduced by 15 months of age

short photoreceptor inner segment ( J:320011 )

• photoreceptor inner segment is significantly shortened at 15 months of age, as shown by decreased Na-K ATPase staining

short photoreceptor outer segment ( J:320011 )

• photoreceptor outer segment is significantly shortened at 12 and 15 months of age, as shown by decreased rhodopsin staining

retina photoreceptor degeneration ( J:320011 )

• mice show late-onset degeneration of photoreceptor cells

retina cone cell degeneration ( J:320011 )

• progressive degeneration of cone cells

retina rod cell degeneration ( J:320011 )

• progressive degeneration of rod cells

decreased a-wave amplitude ( J:320011 )

• mean a-wave amplitudes are reduced by ~15% in scotopic response tests

decreased b-wave amplitude ( J:320011 )

• mean b-wave amplitudes are reduced by ~30% in scotopic response tests

abnormal eye electrophysiology ( J:320011 )

• all mice show attenuated electroretinogram (ERG) responses around 8 months of age

• however, ERG responses are normal at 6 months of age

abnormal cone electrophysiology ( J:320011 )

• all mice exhibit reduced photopic responses at 8 months of age with a somewhat flat wave under light-adapted conditions

abnormal rod electrophysiology ( J:320011 )

• all mice exhibit reduced scotopic responses at 8 months of age