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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr158+
wild type
MGI:6860621
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Igkctm1(IGKC)Mnz/Igkc+
Rr158tm1(Igh)Xu/Rr158+ 		Not Specified MGI:3758451


Genotype
MGI:3758451
cx1
Allelic
Composition		 Igkctm1(IGKC)Mnz/Igkc+
Rr158tm1(Igh)Xu/Rr158+
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igkctm1(IGKC)Mnz mutation (2 available); any Igkc mutation (9 available)
Rr158tm1(Igh)Xu mutation (0 available); any Rr158 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system morphology ( J:124407 )
• the efficiency of rearrangement of the Igk-Eiktm1(Igh)Xu allele is lower than that of the wild-type allele
decreased B cell number ( J:124407 )
• the percent of mouse immunoglobin kappa+ B cells is reduced with the ratio of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells of about 6:1 compared to equal number of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells when the wild-type Igk allele is present instead of Igk-Eiktm1(Igh)Xu

hematopoietic system
decreased B cell number ( J:124407 )
• the percent of mouse immunoglobin kappa+ B cells is reduced with the ratio of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells of about 6:1 compared to equal number of human immunoglobin kappa+ to mouse immunoglobin kappa+ B cells when the wild-type Igk allele is present instead of Igk-Eiktm1(Igh)Xu




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory