immune system
| N |
• 2-3 week-old mice have peripheral B cell in normal numbers with unmodified kappa/lamda ratios
• bone marrow cells show normal proportions of pro-B, pre-B, and immature B cells in 4-6 week-old mice
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• in mutants, a significant decrease (~80%) in immunoglobulin gene Vkappa- Jkappa rearrangement
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