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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rr133+
wild type
MGI:6856825
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hand1tm1Eno/Hand1tm2Eno
Rr133tm1Eno/Rr133+
Tg(Nkx2-5-cre)9Eno/0 		either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) MGI:3514076
cx2
 		Rr133tm1Eno/Rr133+
Hand2tm2Eno/Hand2tm2Eno 		involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3838384


Genotype
MGI:3514076
cn1
Allelic
Composition		 Hand1tm1Eno/Hand1tm2Eno
Rr133tm1Eno/Rr133+
Tg(Nkx2-5-cre)9Eno/0
Genetic
Background		 either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1Eno mutation (1 available); any Hand1 mutation (14 available)
Hand1tm2Eno mutation (0 available); any Hand1 mutation (14 available)
Rr133tm1Eno mutation (0 available); any Rr133 mutation (0 available)
Tg(Nkx2-5-cre)9Eno mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:94514 )
• no mutant embryos are found after E10.5

cardiovascular system
abnormal myocardial trabeculae morphology ( J:94514 )
• at E10.5 the myocardium is poorly trabeculated
thin myocardium ( J:94514 )
• at E10.5 the myocardium is thin

embryo
embryonic growth retardation ( J:94514 )
• at E10.5 mutant embryos appear slightly delayed compared to compound heterozygotes lacking only Hand1

muscle
abnormal myocardial trabeculae morphology ( J:94514 )
• at E10.5 the myocardium is poorly trabeculated
thin myocardium ( J:94514 )
• at E10.5 the myocardium is thin

growth/size/body
embryonic growth retardation ( J:94514 )
• at E10.5 mutant embryos appear slightly delayed compared to compound heterozygotes lacking only Hand1




Genotype
MGI:3838384
cx2
Allelic
Composition		 Rr133tm1Eno/Rr133+
Hand2tm2Eno/Hand2tm2Eno
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2tm2Eno mutation (0 available); any Hand2 mutation (13 available)
Rr133tm1Eno mutation (0 available); any Rr133 mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:146638 )
• mice die at P1 due to a failure to suckle

craniofacial
abnormal mandibular angle morphology ( J:146638 )
• the angle between the right and left mandibular bones is wider than in wild-type mice
mandible hypoplasia ( J:146638 )
• mandibles are hypoplastic and foreshortened compared to in wild-type mice
abnormal secondary palate development ( J:146638 )
• the secondary palate is not formed unlike in wild-type mice
cleft secondary palate ( J:146638 )
• secondary palate was not formed
failure of palatal shelf elevation ( J:146638 )
• the palatal processes do not elevate

hearing/vestibular/ear
decreased tympanic ring size ( J:146638 )
• shortened and deformed

behavior/neurological
absent suckling reflex ( J:146638 )
• mice fail to suckle at birth

digestive/alimentary system
abnormal secondary palate development ( J:146638 )
• the secondary palate is not formed unlike in wild-type mice
cleft secondary palate ( J:146638 )
• secondary palate was not formed
failure of palatal shelf elevation ( J:146638 )
• the palatal processes do not elevate

skeleton
abnormal mandibular angle morphology ( J:146638 )
• the angle between the right and left mandibular bones is wider than in wild-type mice
mandible hypoplasia ( J:146638 )
• mandibles are hypoplastic and foreshortened compared to in wild-type mice

growth/size/body
abnormal secondary palate development ( J:146638 )
• the secondary palate is not formed unlike in wild-type mice
cleft secondary palate ( J:146638 )
• secondary palate was not formed
failure of palatal shelf elevation ( J:146638 )
• the palatal processes do not elevate




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory