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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rr133+
wild type
MGI:6856825
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
\Hand1tm1Eno/\Hand1tm2Eno
\Rr133tm1Eno/\Rr133+
\Tg(Nkx2-5-cre)9Eno/0
either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6) MGI:3514076
cx2
\Rr133tm1Eno/\Rr133+
\Hand2tm2Eno/\Hand2tm2Eno
involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:3838384


Genotype
MGI:3514076
cn1
Allelic
Composition
\Hand1tm1Eno/\Hand1tm2Eno
\Rr133tm1Eno/\Rr133+
\Tg(Nkx2-5-cre)9Eno/0
Genetic
Background
either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand1tm1Eno mutation (1 available); any Hand1 mutation (14 available)
Hand1tm2Eno mutation (0 available); any Hand1 mutation (14 available)
Rr133tm1Eno mutation (0 available); any Rr133 mutation (0 available)
Tg(Nkx2-5-cre)9Eno mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mutant embryos are found after E10.5

cardiovascular system
• at E10.5 the myocardium is poorly trabeculated
• at E10.5 the myocardium is thin

embryo
• at E10.5 mutant embryos appear slightly delayed compared to compound heterozygotes lacking only Hand1

muscle
• at E10.5 the myocardium is poorly trabeculated
• at E10.5 the myocardium is thin

growth/size/body
• at E10.5 mutant embryos appear slightly delayed compared to compound heterozygotes lacking only Hand1




Genotype
MGI:3838384
cx2
Allelic
Composition
\Rr133tm1Eno/\Rr133+
\Hand2tm2Eno/\Hand2tm2Eno
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2tm2Eno mutation (0 available); any Hand2 mutation (13 available)
Rr133tm1Eno mutation (0 available); any Rr133 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die at P1 due to a failure to suckle

craniofacial
• the angle between the right and left mandibular bones is wider than in wild-type mice
• mandibles are hypoplastic and foreshortened compared to in wild-type mice
• the secondary palate is not formed unlike in wild-type mice
• secondary palate was not formed
• the palatal processes do not elevate

hearing/vestibular/ear
• shortened and deformed

behavior/neurological
• mice fail to suckle at birth

digestive/alimentary system
• the secondary palate is not formed unlike in wild-type mice
• secondary palate was not formed
• the palatal processes do not elevate

skeleton
• the angle between the right and left mandibular bones is wider than in wild-type mice
• mandibles are hypoplastic and foreshortened compared to in wild-type mice

growth/size/body
• the secondary palate is not formed unlike in wild-type mice
• secondary palate was not formed
• the palatal processes do not elevate





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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory