Phenotypes associated with this allele

• Allele Symbol: Lyplal1^em1Espel
• Allele Name: endonuclease-mediated mutation 1, Elizabeth Speliotes
• Allele ID: MGI:6856579
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lyplal1^em1Espel/Lyplal1^em1Espel	C57BL/6J-Lyplal1^em1Espel	MGI:7547105

Genotype
MGI:7547105

hm1

• Allelic Composition: Lyplal1^em1Espel/Lyplal1^em1Espel
• Genetic Background: C57BL/6J-Lyplal1^em1Espel

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:340413 )

♀N • female mice fed a high-fat, high-salt diet exhibit normal food intake, energy expenditure, and fuel utilization

decreased susceptibility to diet-induced obesity ( J:340413 )

♀ • female mice fed a high-fat, high-salt diet exhibit reduced body weight gain compared with wild-type mice

♀ • however, male mice exhibit normal weight gain

increased circulating triglyceride level ( J:340413 )

♀ • in female mice fed a high-fat, high-salt diet (HFHS)

♀ • however, mice fed standard chow and male mice a HFHS diet exhibit normal serum triglycerides levels

decreased circulating alanine transaminase level ( J:340413 )

♀ • in female mice fed a high-fat, high-salt diet (HFHS)

♀ • however, mice fed standard chow and male mice a HFHS diet exhibit levels of liver damage markers

decreased circulating aspartate transaminase level ( J:340413 )

♀ • in female mice fed a high-fat, high-salt diet (HFHS)

♀ • however, mice fed standard chow and male mice a HFHS diet exhibit levels of liver damage markers

abnormal glucose homeostasis ( J:340413 )

♀ • female mice fed a high-fat, high-salt diet fail to exhibit impaired glucose tolerance and insulin resistance unlike male and wild-type mice

decreased liver triglyceride level ( J:340413 )

• mice fed a high-fat, high-salt diet

• however, mice fed standard chow exhibit normal liver triglyceride levels

adipose tissue

decreased white adipose tissue amount ( J:340413 )

♀ • in female mice fed a high-fat, high-salt diet

♀ • however, brown adipose levels remain the same as in wild-type

decreased white fat cell size ( J:340413 )

♀ • in female mice fed a high-fat, high-salt diet

growth/size/body

decreased susceptibility to diet-induced obesity ( J:340413 )

♀ • female mice fed a high-fat, high-salt diet exhibit reduced body weight gain compared with wild-type mice

♀ • however, male mice exhibit normal weight gain

liver/biliary system

decreased liver triglyceride level ( J:340413 )

• mice fed a high-fat, high-salt diet

• however, mice fed standard chow exhibit normal liver triglyceride levels

decreased susceptibility to diet-induced hepatic steatosis ( J:340413 )

• mice fed a high-fat, high-salt diet

• however, mice fed standard chow exhibit normal levels of macrosteatosis