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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mcrip2em1Eno
endonuclease-mediated mutation 1, Eric N Olson
MGI:6845074
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mcrip2em1Eno/Mcrip2em1Eno C57BL/6N-Mcrip2em1Eno MGI:6845079


Genotype
MGI:6845079
hm1
Allelic
Composition		 Mcrip2em1Eno/Mcrip2em1Eno
Genetic
Background		 C57BL/6N-Mcrip2em1Eno
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcrip2em1Eno mutation (0 available); any Mcrip2 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
whitened brown adipose tissue morphology ( J:316902 )
• lighter and hypertrophied brown adipose tissue
abnormal brown adipose tissue physiology ( J:316902 )
• aberrant branched-chain amino acid and fatty acid metabolism

homeostasis/metabolism
impaired adaptive thermogenesis ( J:316902 )
• severely hypothermia after cold exposure with persistent hyperlipidemia unlike wild-type mice

muscle
muscle phenotype ( J:316902 )
N
• mice exhibit normal skeletal muscle function




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory