All Phenotypes Dppa2<tm2.1Reik> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dppa2^tm2.1Reik
targeted mutation 2.1, Wolf Reik
MGI:6842977

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dppa2^tm2.1Reik/Dppa2^tm2.1Reik Dppa4^tm2.1Reik/Dppa4^tm2.1Reik Tmem163^{Tg(ACTB-cre)2Mrt}/Tmem163⁺	involves: C57BL/6 * FVB/N	MGI:6845063

Allelic Composition	Dppa2^tm2.1Reik/Dppa2^tm2.1Reik Dppa4^tm2.1Reik/Dppa4^tm2.1Reik Tmem163^{Tg(ACTB-cre)2Mrt}/Tmem163⁺
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dppa2^tm2.1Reik mutation (0 available); any Dppa2 mutation (27 available)
Dppa4^tm2.1Reik mutation (0 available); any Dppa4 mutation (33 available)
Tmem163^{Tg(ACTB-cre)2Mrt} mutation (3 available); any Tmem163 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

maternal effect ( J:316936 )

• fewer than expected mice are produced in the absence of maternal and zygotic Dppa2 and Dppa4 expression with high lethality by P3

• however, female mice mated to wild-type male mice exhibit embryos that develop normal blastocysts

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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