Phenotypes associated with this allele

• Allele Symbol: Mrps12^em1.2Afi
• Allele Name: endonuclease-mediated mutation 1.2, Aleksandra Filipovska
• Allele ID: MGI:6842911
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mrps12^em1.2Afi/Mrps12^em1.2Afi	B6N(Cg)-Mrps12^em1.2Afi	MGI:6842944

Genotype
MGI:6842944

hm1

• Allelic Composition: Mrps12^em1.2Afi/Mrps12^em1.2Afi
• Genetic Background: B6N(Cg)-Mrps12^em1.2Afi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased mitochondrial DNA content ( J:284101 )

• in 30-week-old livers

increased hepatocyte proliferation ( J:284101 )

• in 30-week-old livers

abnormal mitochondrial ATP synthesis coupled electron transport ( J:284101 )

• reduced levels of complex IV in the liver mitochondria at 10 weeks but not 30 weeks

• however, complex IV levels are normal in heart mitochondria and 30-week-old mice exhibit normal mitochondrial oxygen consumption

abnormal translation ( J:284101 )

• reduced overall mitochondrial translation

homeostasis/metabolism

abnormal translation ( J:284101 )

• reduced overall mitochondrial translation

increased cholesterol level ( J:284101 )

• in the mitochondria from 10-week-old mice

liver/biliary system

increased hepatocyte proliferation ( J:284101 )

• in 30-week-old livers

abnormal hepatocyte morphology ( J:284101 )

• increased polyploid cells in 30-week-old livers