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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ahcyem1Cya
endonuclease-mediated mutation 1, Cyagen Biosciences
MGI:6838413
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ahcyem1Cya/Ahcy+ C57BL/6N-Ahcyem1Cya/Cya MGI:6840217


Genotype
MGI:6840217
ht1
Allelic
Composition		 Ahcyem1Cya/Ahcy+
Genetic
Background		 C57BL/6N-Ahcyem1Cya/Cya
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahcyem1Cya mutation (0 available); any Ahcy mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal vasodilation ( J:298071 )
• in response to precontraction with phenylephrine and relaxation with acetylcholine, mice with or without indomethacin exhibit endothelial dysfunction compared with control mice
• however, relaxation in response to nitroprusside is normal

cellular

homeostasis/metabolism
abnormal nitric oxide homeostasis ( J:298071 )
• reduced aortic concentration in response to precontraction with phenylephrine and relaxation with acetylcholine

muscle
abnormal vasodilation ( J:298071 )
• in response to precontraction with phenylephrine and relaxation with acetylcholine, mice with or without indomethacin exhibit endothelial dysfunction compared with control mice
• however, relaxation in response to nitroprusside is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory