Phenotypes associated with this allele

• Allele Symbol: Cenpv^{tm1d(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:6838384
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cenpv^tm1d(EUCOMM)Hmgu/Cenpv^tm1d(EUCOMM)Hmgu	involves: C57BL/6N	MGI:6838388

Genotype
MGI:6838388

hm1

• Allelic Composition: Cenpv^{tm1d(EUCOMM)Hmgu}/Cenpv^{tm1d(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:314905 )

♂N • male mice exhibit normal fertility

abnormal female meiosis ( J:314905 )

♀ • increased time to undergo germinal vesicle breakdown in culture and time to extrude the first polar body

♀ • 4-fold increase in aneuploidy rates

♀ • delayed and erroneous chromosome alignment

♀ • impaired chromosome-microtubule attachment in metaphase I and II

♀ • however, older mice exhibit normal polar body extrusion

impaired polar body extrusion ( J:314905 )

♀ • increased time to extrude the first polar body

abnormal meiotic spindle morphology ( J:314905 )

♀ • reduced spindle integrity in oocytes

reduced female fertility ( J:314905 )

♀

cellular

abnormal female meiosis ( J:314905 )

♀ • increased time to undergo germinal vesicle breakdown in culture and time to extrude the first polar body

♀ • 4-fold increase in aneuploidy rates

♀ • delayed and erroneous chromosome alignment

♀ • impaired chromosome-microtubule attachment in metaphase I and II

♀ • however, older mice exhibit normal polar body extrusion

impaired polar body extrusion ( J:314905 )

♀ • increased time to extrude the first polar body

abnormal meiotic spindle morphology ( J:314905 )

♀ • reduced spindle integrity in oocytes